Differentiating lung neuroendocrine neoplasms from tumor-like infection using CT in patients with ectopic ACTH syndrome

Objectives Pulmonary neuroendocrine neoplasms (NENs) are the most frequent cause of ectopic adrenocorticotropic hormone syndrome (EAS); lung infection is common in EAS. An imaging finding of infection in EAS patients can mimic NENs. This retrospective study investigated EAS-associated pulmonary imag...

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Bibliographic Details
Published in:Insights into imaging 2024-08, Vol.15 (1), p.187-14, Article 187
Main Authors: Song, Lan, Miao, Hui, Zhu, Zhenchen, Zhu, Huijuan, Wang, Jinhua, Xing, Xiaoping, Zhu, Zhaohui, Jiang, Yuanyuan, Feng, Ruie, Xiao, Yu, Duan, Lian, Sui, Xin, Liu, Qingxing, Wang, Linjie, Chen, Shi, Song, Wei, Jin, Zhengyu, Lu, Lin
Format: Article
Language:English
Subjects:
Atelectasis
Computed tomography
Diagnosis
Diagnostic Radiology
Ectopic ACTH syndrome
Exudation
Fingers
Health services
Imaging
Infections
Internal Medicine
Interventional Radiology
Lesions
Localization
Lungs
Medical imaging
Medicine
Medicine & Public Health
Neoplasms
Neuroendocrine tumors
Neuroradiology
Original Article
Oxygen content
Positron emission
Pulmonary infection
Pulmonary lesions
Radiology
Sensitivity analysis
Tomography (x-ray computed)
Tumors
Ultrasound
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Summary:Objectives Pulmonary neuroendocrine neoplasms (NENs) are the most frequent cause of ectopic adrenocorticotropic hormone syndrome (EAS); lung infection is common in EAS. An imaging finding of infection in EAS patients can mimic NENs. This retrospective study investigated EAS-associated pulmonary imaging indicators. Methods Forty-five pulmonary NENs and 27 tumor-like infections from 59 EAS patients (45 NEN and 14 infection patients) were included. Clinical manifestations, CT features, 18 F-FDG, or 68 Ga-DOTATATE-PET/CT images and pathological results were collected. Results High-sensitivity C-reactive protein ( p  
ISSN:1869-4101
1869-4101
DOI:10.1186/s13244-024-01775-9