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Ciprofloxacin loaded PEG coated ZnO nanoparticles with enhanced antibacterial and wound healing effects
Antimicrobial resistance is a worldwide health problem that demands alternative antibacterial strategies. Modified nano-composites can be an effective strategy as compared to traditional medicine. The current study was designed to develop a biocompatible nano-drug delivery system with increased effi...
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| Published in: | Scientific reports 2024-02, Vol.14 (1), p.4689-18, Article 4689 |
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| creator | Ibne Shoukani, Hussan Nisa, Sobia Bibi, Yamin Zia, Muhammad Sajjad, Anila Ishfaq, Afsheen Ali, Hussain |
| description | Antimicrobial resistance is a worldwide health problem that demands alternative antibacterial strategies. Modified nano-composites can be an effective strategy as compared to traditional medicine. The current study was designed to develop a biocompatible nano-drug delivery system with increased efficacy of current therapeutics for biomedical applications. Zinc oxide nanoparticles (ZnO-NPs) were synthesized by chemical and green methods by mediating with
Moringa olifera
root extract. The ZnO–NPs were further modified by drug conjugation and coating with PEG (CIP-PEG-ZnO-NPs) to enhance their therapeutic potential. PEGylated ZnO-ciprofloxacin nano-conjugates were characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry, and Scanning Electron Microscopy. During antibacterial screenings chemically and green synthesized CIP-PEG-ZnO-NPs revealed significant activity against clinically isolated Gram-positive and Gram-negative bacterial strains. The sustainable and prolonged release of antibiotics was noted from the CIP–PEG conjugated ZnO-NPs. The synthesized nanoparticles were found compatible with RBCs and Baby hamster kidney cell lines (BHK21) during hemolytic and MTT assays respectively. Based on initial findings a broad-spectrum nano-material was developed and tested for biomedical applications that eradicated
Staphylococcus aureus
from the infectious site and showed wound-healing effects during in vivo applications. ZnO-based nano-drug carrier can offer targeted drug delivery, and improved drug stability and efficacy resulting in better drug penetration. |
| doi_str_mv | 10.1038/s41598-024-55306-z |
| format | article |
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Moringa olifera
root extract. The ZnO–NPs were further modified by drug conjugation and coating with PEG (CIP-PEG-ZnO-NPs) to enhance their therapeutic potential. PEGylated ZnO-ciprofloxacin nano-conjugates were characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry, and Scanning Electron Microscopy. During antibacterial screenings chemically and green synthesized CIP-PEG-ZnO-NPs revealed significant activity against clinically isolated Gram-positive and Gram-negative bacterial strains. The sustainable and prolonged release of antibiotics was noted from the CIP–PEG conjugated ZnO-NPs. The synthesized nanoparticles were found compatible with RBCs and Baby hamster kidney cell lines (BHK21) during hemolytic and MTT assays respectively. Based on initial findings a broad-spectrum nano-material was developed and tested for biomedical applications that eradicated
Staphylococcus aureus
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Moringa olifera
root extract. The ZnO–NPs were further modified by drug conjugation and coating with PEG (CIP-PEG-ZnO-NPs) to enhance their therapeutic potential. PEGylated ZnO-ciprofloxacin nano-conjugates were characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry, and Scanning Electron Microscopy. During antibacterial screenings chemically and green synthesized CIP-PEG-ZnO-NPs revealed significant activity against clinically isolated Gram-positive and Gram-negative bacterial strains. The sustainable and prolonged release of antibiotics was noted from the CIP–PEG conjugated ZnO-NPs. The synthesized nanoparticles were found compatible with RBCs and Baby hamster kidney cell lines (BHK21) during hemolytic and MTT assays respectively. Based on initial findings a broad-spectrum nano-material was developed and tested for biomedical applications that eradicated
Staphylococcus aureus
from the infectious site and showed wound-healing effects during in vivo applications. 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Modified nano-composites can be an effective strategy as compared to traditional medicine. The current study was designed to develop a biocompatible nano-drug delivery system with increased efficacy of current therapeutics for biomedical applications. Zinc oxide nanoparticles (ZnO-NPs) were synthesized by chemical and green methods by mediating with
Moringa olifera
root extract. The ZnO–NPs were further modified by drug conjugation and coating with PEG (CIP-PEG-ZnO-NPs) to enhance their therapeutic potential. PEGylated ZnO-ciprofloxacin nano-conjugates were characterized by Fourier Transform Infrared spectroscopy, X-ray diffractometry, and Scanning Electron Microscopy. During antibacterial screenings chemically and green synthesized CIP-PEG-ZnO-NPs revealed significant activity against clinically isolated Gram-positive and Gram-negative bacterial strains. The sustainable and prolonged release of antibiotics was noted from the CIP–PEG conjugated ZnO-NPs. The synthesized nanoparticles were found compatible with RBCs and Baby hamster kidney cell lines (BHK21) during hemolytic and MTT assays respectively. Based on initial findings a broad-spectrum nano-material was developed and tested for biomedical applications that eradicated
Staphylococcus aureus
from the infectious site and showed wound-healing effects during in vivo applications. ZnO-based nano-drug carrier can offer targeted drug delivery, and improved drug stability and efficacy resulting in better drug penetration.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38409460</pmid><doi>10.1038/s41598-024-55306-z</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2024-02, Vol.14 (1), p.4689-18, Article 4689 |
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| subjects | 631/1647 631/326 631/61 639/301 Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial Antibiotics Antimicrobial resistance Broad-spectrum Cell lines CIP-PEG-ZnO-NPs Ciprofloxacin Ciprofloxacin - pharmacology Cytotoxic effects Drug delivery Drug delivery systems Fourier transforms Humanities and Social Sciences Infrared spectroscopy Metal Nanoparticles - chemistry Microbial Sensitivity Tests Microscopy, Electron, Scanning multidisciplinary Nano-drug delivery system Nanocomposites Nanoparticles Nanoparticles - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Polyethylene glycol Scanning electron microscopy Science Science (multidisciplinary) Spectroscopy, Fourier Transform Infrared Wound healing Zinc oxide Zinc Oxide - chemistry Zinc oxides |
| title | Ciprofloxacin loaded PEG coated ZnO nanoparticles with enhanced antibacterial and wound healing effects |
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