Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collec...

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Bibliographic Details
Published in:Cancer management and research 2018-01, Vol.10, p.1781-1789
Main Authors: Xiao, Yong-Bo, Cai, Shao-Hang, Liu, Li-Li, Yang, Xia, Yun, Jing-Ping
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Cancer
Carcinoma
Care and treatment
Cell growth
Cytoplasm
Fatty acids
Genetic aspects
Hepatocellular carcinoma
Kinases
Lipid metabolism
Lipids
Liver
Liver cancer
Medical ethics
Metabolism
Metabolites
Original Research
Ovarian cancer
Oxidation-reduction reactions
Pathology
Patient outcomes
Peroxisome proliferator-activated receptors α
prognostic biomarker
Proteins
Risk factors
Statistical analysis
Studies
Transcription factors
Treatment outcome
Tumors
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Summary:Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed. Kaplan-Meier analysis was conducted to assess the prognostic value of PPARα expression levels. The expression of PPARα in HCC was noticeably decreased in HCC tissues. HCC patients with high levels of PPARα expression in cytoplasm had smaller tumors ( =0.027), less vascular invasion ( =0.049), and a higher proportion of complete involucrum ( =0.038). Kaplan-Meier analysis showed that HCC patients with low PPARα expression in the cytoplasm had significantly worse outcomes in terms of overall survival (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S166971