Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collec...

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Published in:Cancer management and research 2018-01, Vol.10, p.1781-1789
Main Authors: Xiao, Yong-Bo, Cai, Shao-Hang, Liu, Li-Li, Yang, Xia, Yun, Jing-Ping
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Cancer
Carcinoma
Care and treatment
Cell growth
Cytoplasm
Fatty acids
Genetic aspects
Hepatocellular carcinoma
Kinases
Lipid metabolism
Lipids
Liver
Liver cancer
Medical ethics
Metabolism
Metabolites
Original Research
Ovarian cancer
Oxidation-reduction reactions
Pathology
Patient outcomes
Peroxisome proliferator-activated receptors α
prognostic biomarker
Proteins
Risk factors
Statistical analysis
Studies
Transcription factors
Treatment outcome
Tumors
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Cai, Shao-Hang
Liu, Li-Li
Yang, Xia
Yun, Jing-Ping
description Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed. Kaplan-Meier analysis was conducted to assess the prognostic value of PPARα expression levels. The expression of PPARα in HCC was noticeably decreased in HCC tissues. HCC patients with high levels of PPARα expression in cytoplasm had smaller tumors ( =0.027), less vascular invasion ( =0.049), and a higher proportion of complete involucrum ( =0.038). Kaplan-Meier analysis showed that HCC patients with low PPARα expression in the cytoplasm had significantly worse outcomes in terms of overall survival (
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Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed. Kaplan-Meier analysis was conducted to assess the prognostic value of PPARα expression levels. The expression of PPARα in HCC was noticeably decreased in HCC tissues. HCC patients with high levels of PPARα expression in cytoplasm had smaller tumors ( =0.027), less vascular invasion ( =0.049), and a higher proportion of complete involucrum ( =0.038). Kaplan-Meier analysis showed that HCC patients with low PPARα expression in the cytoplasm had significantly worse outcomes in terms of overall survival ( &lt;0.001), disease-free survival ( =0.024), and the probability of recurrence ( =0.037). Similarly, overall survival was significantly shorter in HCC patients with negative PPARα expression in the nucleus ( =0.034). Multivariate Cox analyses indicated that tumor size ( =0.001), TNM stage ( &lt;0.001), vascular invasion ( &lt;0.001), and PPARα expression in the cytoplasm ( &lt;0.001) were found to be independent prognostic variables for overall survival. Our data revealed that PPARα expression was decreased in HCC samples. High PPARα expression was correlated with longer survival times in HCC patients, and served as an independent factor for better outcomes. 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Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed. Kaplan-Meier analysis was conducted to assess the prognostic value of PPARα expression levels. The expression of PPARα in HCC was noticeably decreased in HCC tissues. HCC patients with high levels of PPARα expression in cytoplasm had smaller tumors ( =0.027), less vascular invasion ( =0.049), and a higher proportion of complete involucrum ( =0.038). Kaplan-Meier analysis showed that HCC patients with low PPARα expression in the cytoplasm had significantly worse outcomes in terms of overall survival ( &lt;0.001), disease-free survival ( =0.024), and the probability of recurrence ( =0.037). Similarly, overall survival was significantly shorter in HCC patients with negative PPARα expression in the nucleus ( =0.034). Multivariate Cox analyses indicated that tumor size ( =0.001), TNM stage ( &lt;0.001), vascular invasion ( &lt;0.001), and PPARα expression in the cytoplasm ( &lt;0.001) were found to be independent prognostic variables for overall survival. Our data revealed that PPARα expression was decreased in HCC samples. High PPARα expression was correlated with longer survival times in HCC patients, and served as an independent factor for better outcomes. 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Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. A total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed. Kaplan-Meier analysis was conducted to assess the prognostic value of PPARα expression levels. The expression of PPARα in HCC was noticeably decreased in HCC tissues. HCC patients with high levels of PPARα expression in cytoplasm had smaller tumors ( =0.027), less vascular invasion ( =0.049), and a higher proportion of complete involucrum ( =0.038). Kaplan-Meier analysis showed that HCC patients with low PPARα expression in the cytoplasm had significantly worse outcomes in terms of overall survival ( &lt;0.001), disease-free survival ( =0.024), and the probability of recurrence ( =0.037). Similarly, overall survival was significantly shorter in HCC patients with negative PPARα expression in the nucleus ( =0.034). Multivariate Cox analyses indicated that tumor size ( =0.001), TNM stage ( &lt;0.001), vascular invasion ( &lt;0.001), and PPARα expression in the cytoplasm ( &lt;0.001) were found to be independent prognostic variables for overall survival. Our data revealed that PPARα expression was decreased in HCC samples. High PPARα expression was correlated with longer survival times in HCC patients, and served as an independent factor for better outcomes. Our study therefore provides a promising biomarker for prognostic prediction and a potential therapeutic target for HCC.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>29983595</pmid><doi>10.2147/CMAR.S166971</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Analysis
Breast cancer
Cancer
Carcinoma
Care and treatment
Cell growth
Cytoplasm
Fatty acids
Genetic aspects
Hepatocellular carcinoma
Kinases
Lipid metabolism
Lipids
Liver
Liver cancer
Medical ethics
Metabolism
Metabolites
Original Research
Ovarian cancer
Oxidation-reduction reactions
Pathology
Patient outcomes
Peroxisome proliferator-activated receptors α
prognostic biomarker
Proteins
Risk factors
Statistical analysis
Studies
Transcription factors
Treatment outcome
Tumors
title Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma
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