P-N Junction-Based Si Biochips with Ring Electrodes for Novel Biosensing Applications

In this work, we report on the impedance of p-n junction-based Si biochips with gold ring top electrodes and unstructured platinum bottom electrodes which allows for counting target biomaterial in a liquid-filled ring top electrode region. The systematic experiments on p-n junction-based Si biochips...

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Bibliographic Details
Published in:Biosensors (Basel) 2019-10, Vol.9 (4), p.120
Main Authors: Kiani, Mahdi, Du, Nan, Vogel, Manja, Raff, Johannes, Hübner, Uwe, Skorupa, Ilona, Bürger, Danilo, Schulz, Stefan E, Schmidt, Oliver G, Schmidt, Heidemarie
Format: Article
Language:English
Subjects:
Bacillaceae
Bacteria
Biochips
Biocompatible Materials - chemistry
biomaterial
Biomaterials
Biomedical materials
Biomonitoring
Biosensing Techniques
Biosensors
Capacitance
Cell Count
Chromatography
Deionization
Electric Impedance
electrical equivalent circuit
Electrodes
Equivalent circuits
Gold
Human error
Impedance
impedance spectroscopy
lysinibacillus sphaericus jg-a12
Microscopy
Optical density
P-n junctions
Parameters
Platinum
Platinum - chemistry
Silicon - chemistry
Silicon wafers
Software
Spectrum analysis
Surgical implants
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Summary:In this work, we report on the impedance of p-n junction-based Si biochips with gold ring top electrodes and unstructured platinum bottom electrodes which allows for counting target biomaterial in a liquid-filled ring top electrode region. The systematic experiments on p-n junction-based Si biochips fabricated by two different sets of implantation parameters (i.e. biochips PS5 and BS5) are studied, and the comparable significant change of impedance characteristics in the biochips in dependence on the number of bacteria suspension, i.e., JG-A12, in Deionized water with an optical density at 600 nm from OD = 4-16 in the electrode ring region is demonstrated. Furthermore, with the help of the newly developed two-phase electrode structure, the modeled capacitance and resistance parameters of the electrical equivalent circuit describing the p-n junction-based biochips depend linearly on the number of bacteria in the ring top electrode region, which successfully proves the potential performance of p-n junction-based Si biochips in observing the bacterial suspension. The proposed p-n junction-based biochips reveal perspective applications in medicine and biology for diagnosis, monitoring, management, and treatment of diseases.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios9040120