Bidirectional associations between periodontal disease and systemic diseases: a nationwide population-based study in Korea

To evaluate the associations of periodontal disease (PD) with systemic diseases, including diabetes mellitus (DM) and cardiovascular disease (CVD), as well as the reciprocal association. The CVD included the cases of coronary heart disease and heart failure. A prospective study was conducted from 20...

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Bibliographic Details
Published in:Scientific reports 2023-08, Vol.13 (1), p.14078-14078, Article 14078
Main Authors: Nabila, Salma, Choi, Jaesung, Kim, Ji-Eun, Hahn, Seokyung, Hwang, In-Kyung, Kim, Tae-Il, Park, Hee-Kyung, Choi, Ji-Yeob
Format: Article
Language:English
Subjects:
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Body mass index
Cardiovascular disease
Cardiovascular diseases
Congestive heart failure
Coronary artery disease
Diabetes mellitus
Gum disease
Heart diseases
Humanities and Social Sciences
Medical records
multidisciplinary
Periodontal diseases
Population studies
Population-based studies
Science
Science (multidisciplinary)
Systemic diseases
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Summary:To evaluate the associations of periodontal disease (PD) with systemic diseases, including diabetes mellitus (DM) and cardiovascular disease (CVD), as well as the reciprocal association. The CVD included the cases of coronary heart disease and heart failure. A prospective study was conducted from 2007 to 2019 using linked data from three databases in Korea. Three separate study groups were formed to individually determine the risks of PD (n = 10,533), DM (n = 14,523) and CVD (n = 14,315). All diseases were confirmed based on physicians’ diagnoses using medical records and self-reports. Cox proportional hazard regression was applied with 95% confidence intervals (CIs) to obtain hazard ratios (HRs). PD was significantly associated with an elevated risk of DM (HR [95% CI]: 1.22 [1.07–1.39]) after full adjustment for age, sex, lifestyle factors, body mass index, dental behaviour and CVD. PD was also found to increase the risk of CVD (1.27 [1.03–1.57]), whereas CVD increased the risk of PD (1.20 [1.09–1.32]) after full adjustment for other covariates including DM. This study found a bidirectional association between PD and CVD, as well as a positive association of PD with DM.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-41009-4