Sociality deficits in serine racemase knockout mice

• Published in: Brain and behavior 2019-10, Vol.9 (10), p.e01383-n/a
• Main Authors: Matveeva, Tatyana M., Pisansky, Marc T., Young, Amy, Miller, Robert F., Gewirtz, Jonathan C.
• Format: Article
• Language: English
• Subjects: affect; Animal cognition; Animals; asociality; Behavior; Behavior, Animal; Choice Behavior; glutamate; Glutamic Acid - metabolism; Memory; Mice; Mice, Knockout; N‐methyl‐D‐aspartate; Original Research; Racemases and Epimerases - genetics; Receptors, N-Methyl-D-Aspartate - metabolism; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - physiopathology; Schizophrenic Psychology; Serine - metabolism; sociability; Social Behavior; Social interaction; Social research; Vocalization, Animal
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1383

Background Studies of schizophrenia have pointed to the role of glutamate in its pathophysiology. Mice lacking D‐serine show impairments in neurotransmission through NMDA receptors and display behaviors consistent with features of schizophrenia. Yet, socio‐communicative deficits, a characteristic of schizophrenia, have not been reported in serine racemase knockout mice. Methods We use behavioral testing (the three‐chambered social approach task, the dyadic interaction task, and the novel object recognition task) to examine socio‐communicative behaviors in these mice. Results Serine racemase mice show abnormal social investigation and approach behavior, and differ from wild‐type controls in the duration and number of vocalizations they emit in the presence of a conspecific. Serine racemase knockout mice were not impaired in a cognitive test (novel object recognition), although they displayed abnormal behavior in the acquisition phase of the task. Conclusions Serine racemase knockout mice demonstrate abnormalities in socio‐communicative behaviors consistent with an impairment in sociality, a negative symptom of schizophrenia. Studies of schizophrenia have pointed to the role of glutamate in its pathophysiology. Mice lacking D‐serine show impairments in neurotransmission through NMDA receptors and display behaviors consistent with features of schizophrenia. Yet, socio‐communicative deficits, a characteristic of schizophrenia, have not been reported in serine racemase knockout mice. Our findings indicate that these mice show abnormal social investigation and approach behavior.