Association of triglycerides to high-density lipoprotein cholesterol ratio to identify future prediabetes and type 2 diabetes mellitus: over one-decade follow-up in the Iranian population

To determine the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for identifying subjects at risk of incident prediabetes and type 2 diabetes mellitus (T2DM). In 5064 subjects (men = 2247) aged ≥ 20 years, using Cox proportional hazards regression analyses,...

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Published in:Diabetology and metabolic syndrome 2023-02, Vol.15 (1), p.13-13, Article 13
Main Authors: Tohidi, Maryam, Asgari, Samaneh, Chary, Abdolreza, Safiee, Siavash, Azizi, Fereidoun, Hadaegh, Farzad
Format: Article
Language:English
Subjects:
Analysis
Blood pressure
Body mass index
Body measurements
Cardiovascular diseases
Chi-square test
Cholesterol
Design
Diabetes
Diabetes mellitus (non-insulin dependent)
Dysglycemia
Glucose
High density lipoprotein
High-density lipoprotein cholesterol
Homeostasis
Insulin
Insulin resistance
Kidney diseases
Laboratories
Metabolic syndrome
Missing data
Population
Prediabetes
Prediabetic state
Ratio
Statistics
Triglycerides
Type 2 diabetes
Type 2 diabetes mellitus
Womens health
Wrist
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Summary:To determine the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for identifying subjects at risk of incident prediabetes and type 2 diabetes mellitus (T2DM). In 5064 subjects (men = 2247) aged ≥ 20 years, using Cox proportional hazards regression analyses, the associations of TG/HDL-C with incident prediabetes and T2DM were examined among normoglycemic men and women. Furthermore, the association of this lipid ratio with incident T2DM was also assessed among prediabetic subjects (n = 1414). The multivariable analyses were adjusted for age, body mass index, waist-to-height ratio, wrist circumference, systolic blood pressure, family history of T2DM, education level, history of cardiovascular diseases, and fasting plasma glucose (FPG). During a median follow-up of 11.2 years, 2140 new cases of prediabetes (men = 1070) and 360 incident T2DM (men = 152) were identified among normoglycemic individuals. In the prediabetic population, 574 new cases of T2DM (men = 252) were developed. Among the whole population, compared to the first quartile (reference), higher quartiles of TG/HDL-C were significantly associated with higher risks of incident prediabetes and T2DM among normoglycemic individuals and incident T2DM in the prediabetic population (all P for trend 
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-023-00988-0