Reconstruction of time-shifted hemodynamic response

Regression of voxel time course onto expected response is a standard procedure in functional magnetic resonance imaging that relies on exact onset time and shape of superimposed hemodynamic response functions. Elegant capture of time deviation by time derivative regressors appears complicated by sha...

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Bibliographic Details
Published in:Scientific reports 2022-10, Vol.12 (1), p.17441-17441, Article 17441
Main Author: Herrnberger, Bärbel
Format: Article
Language:English
Subjects:
631/114/1314
631/114/2397
631/378/2607
631/378/2613
631/378/3917
Bias
Decomposition
Functional magnetic resonance imaging
Hemodynamics
Hemodynamics - physiology
Humanities and Social Sciences
Latency
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
multidisciplinary
Science
Science (multidisciplinary)
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Summary:Regression of voxel time course onto expected response is a standard procedure in functional magnetic resonance imaging that relies on exact onset time and shape of superimposed hemodynamic response functions. Elegant capture of time deviation by time derivative regressors appears complicated by shape distortion and limited to ±1 s, and is usually not exploited for reconstructing the true time-shifted response function together with its magnitude. This analysis of the time-derivative approach provides closed-form functional relations between time shift and regression coefficients that allow for hemodynamic shifts of ±5 s and can explain shape distortion and reconstruction behavior. Reliable absolute latencies were no smaller than 0.6 s in a best-case experiment. Confusions of latency are a previously undiscussed shortcoming where current limitation strategy may eliminate correct latencies and protect incorrect ones.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-17601-5