Regulatory T Cell Metabolism in Atherosclerosis

Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall...

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Bibliographic Details
Published in:Metabolites 2020-07, Vol.10 (7), p.279
Main Authors: Baardman, Jeroen, Lutgens, Esther
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Antigens
Apolipoproteins
Apoptosis
Arteriosclerosis
Atherosclerosis
Autoimmunity
Cardiovascular disease
Cardiovascular diseases
Cell growth
Cholesterol
Collagen
Cytokines
Foxp3
Homeostasis
immunometabolism
Immunoregulation
Inflammatory diseases
Lymphocytes
Lymphocytes T
Metabolism
Proteins
Review
T cells
Transcription factors
Tregs
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Summary:Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall and the leading cause of cardiovascular disease. Therefore, therapeutic strategies to improve Treg number or function could be beneficial to preventing atherosclerotic disease development. A growing body of evidence shows that intracellular metabolism of Tregs is a key regulator of their proliferation, suppressive function, and stability. Here we evaluate the role of Tregs in atherosclerosis, their metabolic regulation, and the links between their metabolism and atherosclerosis.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo10070279