Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation

Innovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a fusion-emulsification method, to increase skin permeation and in vivo activ...

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Bibliographic Details
Published in:Pharmaceutics 2021-03, Vol.13 (3), p.328
Main Authors: Mancini, Giuliana, Gonçalves, Lídia M D, Marto, Joana, Carvalho, Filomena A, Simões, Sandra, Ribeiro, Helena Margarida, Almeida, António J
Format: Article
Language:English
Subjects:
anti-inflammatory activity
dermal delivery
etofenamate
hydrogels
ibuprofen
solid lipid nanoparticles (SLN)
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Summary:Innovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a fusion-emulsification method, to increase skin permeation and in vivo activity of two relevant NSAIDs: A liquid molecule (etofenamate) and a solid one (ibuprofen), formulated in a 2% hydroxypropyl methylcellulose gel through the gelation of SLN suspensions. Compritol 888 ATO and Tween 80 were used as a solid lipid and a surfactant, respectively. All production steps were up scalable, resulting in SLNs with high encapsulation efficiency (>90%), a mean particle size of
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13030328