Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

• Published in: Scientific reports 2022-07, Vol.12 (1), p.13148-13148, Article 13148
• Main Authors: Silventoinen, Karri, Piirtola, Maarit, Jelenkovic, Aline, Sund, Reijo, Tarnoki, Adam D., Tarnoki, David L., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Honda, Chika, Inui, Fujio, Tomizawa, Rie, Watanabe, Mikio, Sakai, Norio, Gatz, Margaret, Butler, David A., Lee, Jooyeon, Lee, Soo Ji, Sung, Joohon, Franz, Carol E., Kremen, William S., Lyons, Michael J., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Tynelius, Per, Rasmussen, Finn, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Brandt, Ingunn, Nilsen, Thomas S., Harris, Jennifer R., Tyler, Jessica, Hopper, John L., Magnusson, Patrik K. E., Pedersen, Nancy L., Dahl Aslan, Anna K., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Rebato, Esther, Zhang, Dongfeng, Pang, Zengchang, Tan, Qihua, Silberg, Judy L., Maes, Hermine H., Boomsma, Dorret I., Sørensen, Thorkild I. A., Korhonen, Tellervo, Kaprio, Jaakko
• Format: Article
• Language: English
• Subjects: 631/208; 692/499; adolescence; Child; Children; Cigarette smoking; Drug addiction; Education; Educational attainment; Educational Status; Epidemiology; Genetic factors; Genetics; Humanities and Social Sciences; Humans; maternal smoking; Medicin och hälsovetenskap; Medicine; Mental health; multidisciplinary; Physiology; pregnancy; Public health; Regression analysis; Science; Science (multidisciplinary); Smoking; Smoking - genetics; Smoking Cessation; Social factors; Social research; Twins; Twins, Dizygotic - genetics; Twins, Monozygotic - genetics; Välbefinnande vid långvariga hälsoproblem (WeLHP); Wellbeing in long-term health problems (WeLHP)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-17536-x

We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.