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Cognitive reserve involves decision making and is associated with left parietal and hippocampal hypertrophy in neurodegeneration
Cognitive reserve is the ability to actively cope with brain deterioration and delay cognitive decline in neurodegenerative diseases. It operates by optimizing performance through differential recruitment of brain networks or alternative cognitive strategies. We investigated cognitive reserve using...
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| Published in: | Communications biology 2024-06, Vol.7 (1), p.741-11 |
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| container_end_page | 11 |
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| container_title | Communications biology |
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| creator | Le Stanc, Lorna Lunven, Marine Giavazzi, Maria Sliwinski, Agnès Youssov, Katia Bachoud-Lévi, Anne-Catherine Jacquemot, Charlotte |
| description | Cognitive reserve is the ability to actively cope with brain deterioration and delay cognitive decline in neurodegenerative diseases. It operates by optimizing performance through differential recruitment of brain networks or alternative cognitive strategies. We investigated cognitive reserve using Huntington’s disease (HD) as a genetic model of neurodegeneration to compare premanifest HD, manifest HD, and controls. Contrary to manifest HD, premanifest HD behave as controls despite neurodegeneration. By decomposing the cognitive processes underlying decision making, drift diffusion models revealed a response profile that differs progressively from controls to premanifest and manifest HD. Here, we show that cognitive reserve in premanifest HD is supported by an increased rate of evidence accumulation compensating for the abnormal increase in the amount of evidence needed to make a decision. This higher rate is associated with left superior parietal and hippocampal hypertrophy, and exhibits a bell shape over the course of disease progression, characteristic of compensation.
A study of cognitive reserve in neurodegenerative disease combining drift diffusion models with MRI highlights a reorganization of decision-making processes correlated to left parietal and hippocampal hypertrophy. |
| doi_str_mv | 10.1038/s42003-024-06416-x |
| format | article |
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A study of cognitive reserve in neurodegenerative disease combining drift diffusion models with MRI highlights a reorganization of decision-making processes correlated to left parietal and hippocampal hypertrophy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38890487</pmid><doi>10.1038/s42003-024-06416-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2511-9070</orcidid><orcidid>https://orcid.org/0000-0002-6611-0742</orcidid><orcidid>https://orcid.org/0000-0003-3000-2210</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/2649 631/378/3920 692/617/375/1558 692/617/375/365 Adult Biomedical and Life Sciences Cognitive ability Cognitive Reserve Cognitive science Decision Making Disease Drift Female Hippocampus Hippocampus - pathology Hippocampus - physiopathology Humans Huntington Disease - genetics Huntington Disease - pathology Huntington Disease - physiopathology Huntington Disease - psychology Huntington's disease Huntingtons disease Hypertrophy Life Sciences Male Middle Aged Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Parietal Lobe - pathology Parietal Lobe - physiopathology |
| title | Cognitive reserve involves decision making and is associated with left parietal and hippocampal hypertrophy in neurodegeneration |
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