Synthesis, antifungal activities and qualitative structure activity relationship of carabrone hydrazone derivatives as potential antifungal agents

Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against...

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Bibliographic Details
Published in:International journal of molecular sciences 2014-03, Vol.15 (3), p.4257-4272
Main Authors: Wang, Hao, Ren, Shuang-Xi, He, Ze-Yu, Wang, De-Long, Yan, Xiao-Nan, Feng, Jun-Tao, Zhang, Xing
Format: Article
Language:English
Subjects:
antifungal activity
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial agents
Biological activity
Biosynthesis
Botrytis - drug effects
Botrytis - physiology
Botrytis cinerea
carabrone
chemical modification
Colletotrichum - drug effects
Colletotrichum - physiology
Colletotrichum lagenarium
Fungi
Host-Pathogen Interactions - drug effects
hydrazone derivatives
Hydrazones - chemical synthesis
Hydrazones - chemistry
Hydrazones - pharmacology
Inhibitory Concentration 50
Lycopersicon esculentum - drug effects
Lycopersicon esculentum - microbiology
Microbial Sensitivity Tests
Models, Chemical
Molecular Structure
Mycelium - drug effects
Mycelium - physiology
Species Specificity
Spores, Fungal - drug effects
Spores, Fungal - physiology
Structure-Activity Relationship
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Summary:Aimed at developing novel fungicides for relieving the ever-increasing pressure of agricultural production caused by phytopathogenic fungi, 28 new hydrazone derivatives of carabrone, a natural bioactive sesquisterpene, in three types were designed, synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. The result revealed that all the derivatives synthesized exhibited considerable antifungal activities in vitro and in vivo, which led to the improved activities for carabrone and its analogues and further confirmed their potential as antifungal agents.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms15034257