Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review

With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the metabolism of e...

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Bibliographic Details
Published in:Cell & bioscience 2020-07, Vol.10 (1), p.1-86, Article 86
Main Authors: He, Jie, Qin, Man, Chen, Yingyi, Hu, Ziqi, Xie, Fei, Ye, Ling, Hui, Tianqian
Format: Article
Language:English
Subjects:
Aging
Amino acids
Chronic illnesses
Deoxyribonucleic acid
Development and progression
Diabetes
DNA
DNA methylation
Epigenetic inheritance
Epigenetics
Extracellular matrix
Gene expression
Growth factors
Health aspects
Histone modification
Inflammation
Inflammatory diseases
Matrix metalloproteinase
Matrix metalloproteinases
Medical research
Methylation
microRNAs
Oxidative stress
Phosphorylation
Proteins
Review
Rheumatoid arthritis
Tissue inhibitor of metalloproteinases
Transcription factors
Tuberculosis
Type 2 diabetes
Urbanization
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Summary:With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the metabolism of extracellular matrix (ECM). They play a key role in inflammation-related diseases. Factors such as inflammation, oxidative stress and growth factors stimulate the production of MMPs with subsequent ECM remodeling. Recently, the studies of epigenetic regulation, including the ability to predict disease progression, important pathophysiological deficiencies as well as treatment methods have been extensively discussed. This article reviews the current studies on epigenetic alterations in MMPs during inflammatory response. It is likely to provide new insights into development of efficient medications of epigenetic therapy for inflammatory diseases.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-020-00451-x