Down-regulation of TLR2, 3, 9 and Signaling Mediators, MyD88 and TRIF, Gene Transcript Levels in Patients with Kawasaki Disease Treated with IVIG

Kawasaki disease (KD) is an acute febrile systemic vasculitis of childhood characterized by elevated levels of inflammatory mediators at the acute stage. High-dose intravenous immunoglobulin (IVIG) is well accepted as a conventional therapy for KD. The aim of this present study was to determine the...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2015-04, Vol.14 (2), p.189-189
Main Authors: Mortazavi, Seyed Hamidreza, Amin, Reza, Alyasin, Soheyla, Kashef, Sara, Karimi, Mohammad Hossein, Babayi, Maryam, Younesi, Vahid
Format: Article
Language:English
Subjects:
Bacterial infections
Cytokines
Disease
Fever
Genes
Immune system
IVIG
Kawasaki disease
Medical laboratories
Medical research
MyD88
Studies
Toll like receptors
TRIF
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kawasaki disease (KD) is an acute febrile systemic vasculitis of childhood characterized by elevated levels of inflammatory mediators at the acute stage. High-dose intravenous immunoglobulin (IVIG) is well accepted as a conventional therapy for KD. The aim of this present study was to determine the expression level of Toll like receptors (TLR) and their corresponding signaling mediators in PBMCs of IVIG-treated KD patients. TLR2, 3, 9 and signaling mediators, MyD88 and TRIF transcript levels were determined in PBMCs from 31 KD patients, before (acute phase), 2 weeks later (sub-acute phase) and 6 weeks later (convalescent phase) of IVIG therapy using real time PCR. The mean age of the patients was 3.6 years and 65% of subjects were male and 35% were female. 20 age-matched irrelevant febrile patients and 20 healthy subjects were included as control groups. With Regard to significant up-regulation of MyD88 and TRIF at the acute phase of KD, the findings of this study suggest TLR signaling pathway potential in KD.
ISSN:1735-1502
1735-5249