Lep gene and leptin concentration in serum of schizophrenia patients with metabolic syndrome

IntroductionSchizophrenia is associated with lower life expectancy due to cardiovascular disease. Metabolic syndrome (MetS) occupies an important place among the main problems. Indicators of hormones regulating metabolism may be appealing candidates as biomarkers of metabolic side-effects. Certain r...

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Bibliographic Details
Published in:European psychiatry 2021-04, Vol.64 (S1), p.S164-S164
Main Authors: Boiko, A., Pozhidaev, I., Paderina, D., Kornetova, E., Ivanova, S.
Format: Article
Language:English
Subjects:
Abstract
gene polymorphisms
Genetic research
Hormones
leptin
Metabolic syndrome
Oral Communications
Schizophrenia
schizophrénia
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Summary:IntroductionSchizophrenia is associated with lower life expectancy due to cardiovascular disease. Metabolic syndrome (MetS) occupies an important place among the main problems. Indicators of hormones regulating metabolism may be appealing candidates as biomarkers of metabolic side-effects. Certain role belongs to genetic factors that might be the basis of sensitivity to development of MetS.ObjectivesThe aim is to study polymorphisms of leptin gene (LEP) and serum leptin concentration in schizophrenia patients with metabolic syndrome.MethodsAfter obtaining informed consent, patients with schizophrenia (ICD-10: F20) were included: 91 patients for biochemical research and 463 patients for genotyping. Patients were divided into two groups: 46 (119) with MetS; 45 (344) without it. Concentration of leptin was measured on an analyzer MAGPIX (Luminex, USA). Determination of 4 polymorphisms (rs2167270, rs3828942, rs10954173, rs4731426) of LEP was performed by PCR. Differences were considered significant at p
ISSN:0924-9338
1778-3585
DOI:10.1192/j.eurpsy.2021.438