The effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares

Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA) may affect female reproductive function and embryo tran...

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Bibliographic Details
Published in:BMC veterinary research 2024-12, Vol.20 (1), p.571-571, Article 571
Main Authors: Piotrowska-Tomala, Katarzyna Karolina, Szóstek-Mioduchowska, Anna, Jonczyk, Agnieszka Walentyna, Drzewiecka, Ewa Monika, Wrobel, Michał Hubert, Hojo, Takuo, Ferreira-Dias, Graca, Skarzynski, Dariusz Jan
Format: Article
Language:English
Subjects:
Analysis
Animals
Development and progression
Diseases
Embryonic development
Endometriosis
Endometriosis - genetics
Endometriosis - veterinary
endometritis
endometrium
estrous cycle
Estrous Cycle - drug effects
Female
females
Force of contraction
Genetic aspects
Genetic transcription
Health aspects
Horse Diseases - genetics
Horse Diseases - physiopathology
Horses
Lysophosphatidic acid
Lysophosphatidic acid receptor
lysophospholipids
Lysophospholipids - pharmacology
Mare
Mares
Messenger RNA
Myometrium
Myometrium - drug effects
Myometrium - metabolism
Phospholipids
Receptors, Lysophosphatidic Acid - genetics
Receptors, Lysophosphatidic Acid - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Uterine Contraction - drug effects
Uterus
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Summary:Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA) may affect female reproductive function and embryo transport by influencing uterine contractility through its receptors (LPARs). The objective of this study was to determine myometrial LPAR1-6 mRNA transcription, and the effects of LPA on myometrial contractions in mares with endometrosis during the mid-luteal and follicular phases of the estrous cycle. A reduction in myometrial LPAR1 mRNA transcription was observed in mares with endometrosis during the mid-luteal phase, in comparison to those with category I endometria (P 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-024-04384-2