Challenges and strategies toward oncolytic virotherapy for leptomeningeal metastasis

Meningeal metastasis (LM) is commonly seen in the advanced stages of cancer patients, often leading to a rapid decline in survival time and quality of life. Currently, there is still a lack of standardized treatments. Oncolytic viruses (OVs) are a class of emerging cancer therapeutics with the advan...

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Bibliographic Details
Published in:Journal of translational medicine 2024-11, Vol.22 (1), p.1000-18, Article 1000
Main Authors: Zhao, Jia-Li, Lin, Bi-Lin, Luo, Chen, Yi, Yan-Ling, Huang, Peng, Chen, Yu, Zhao, Sha, Huang, Zhen-Jie, Ma, Xin-Yi, Huang, Long
Format: Article
Language:English
Subjects:
Animals
Cell death
Health aspects
Humans
Immune response
Intra-CSF
Leptomeningeal metastasis
Meningeal Neoplasms - secondary
Meningeal Neoplasms - therapy
Metastasis
Oncolytic virotherapy
Oncolytic Virotherapy - methods
Oncolytic virus
Oncolytic Viruses - physiology
Review
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Summary:Meningeal metastasis (LM) is commonly seen in the advanced stages of cancer patients, often leading to a rapid decline in survival time and quality of life. Currently, there is still a lack of standardized treatments. Oncolytic viruses (OVs) are a class of emerging cancer therapeutics with the advantages of selectively replicating in cancer cells, delivering various eukaryotic transgenes, inducing immunogenic cell death, and promoting anti-tumor immunity. Some studies applying OVs intrathoracically or intraperitoneally for the treatment of malignant pleural and peritoneal effusions have shown promising therapeutic effects. If OVs could be applied to treat LM, it would bring significant survival benefits to patients with LM. In this review, we analyzed past research on the use of viruses to treat meningeal metastasis, summarized the efficacy and safety demonstrated by the research results, and analyzed the feasibility of oncolytic virus therapy for meningeal metastasis. We also summarized the existing data to provide guidance for the development of OVs that can be injected into the cerebrospinal fluid (CSF).
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-024-05794-4