Genetic Variants, Circulating Level of MCP1 with Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study

Chronic obstructive pulmonary disease (COPD) ranks one of the major causes of mortality worldwide. Inflammation is greatly involved in the pathogenesis of COPD. Monocyte chemoattractant protein-1 (MCP1) has been implicated to play an important role in the inflammatory response of various pathologica...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine 2021-01, Vol.14, p.561-567
Main Authors: Lin, Chunyi, Wang, Zhimin, Shen, Lu, Yi, Gao, Li, Meichan, Li, Defu
Format: Article
Language:English
Subjects:
Age
Arthritis
Cardiovascular disease
case-control study
Chemokines
China
Chronic obstructive pulmonary disease
copd
Demographics
Diabetic retinopathy
Gender
Gene polymorphism
genetic
Genetic aspects
Genetic diversity
Genetic polymorphisms
Health aspects
Infection control
Inflammation
Lung diseases
mcp1
Medical research
Medicine, Experimental
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Monocytes
Mortality
Obstructive lung disease
Original Research
Osteoarthritis
Population studies
Regression analysis
Software
Tuberculosis
Type 2 diabetes
variation
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Summary:Chronic obstructive pulmonary disease (COPD) ranks one of the major causes of mortality worldwide. Inflammation is greatly involved in the pathogenesis of COPD. Monocyte chemoattractant protein-1 (MCP1) has been implicated to play an important role in the inflammatory response of various pathological processes. In this study, we conducted a hospital-based case-control study in a Chinese population, aiming to evaluate the potential associations of genetic polymorphisms of the MCP1 gene (rs1024611, rs2857656, and rs4586) and circulating level of MCP1 with COPD risk. We found that rs1024611 (OR=1.37; 95% CI=1.11-1.69; -value=0.004) and rs4586 (OR=1.33; 95% CI=1.09-1.63; -value=0.006) were significantly associated with increased COPD risk. In the dominant model, both rs1024611 (OR=1.46; 95% CI=1.11-1.92; -value=0.006) and rs4586 (OR=1.56; 95% CI=1.18-2.07; -value=0.002) were significantly associated with increased COPD risk. Genotypes of rs1024611 and rs4586 with minor alleles had a significantly higher circulating level of MCP1 (
ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S303799