D-dimer levels as a prognostic factor for determining oncological outcomes in musculoskeletal sarcoma

Plasma d-dimer levels have been associated with the status of tumor progression or oncological outcomes in cancer. Although there are many evidences suggesting the involvement of procoagulant trend in musculoskeletal sarcoma, no clinical data on d-dimer levels and oncological outcome of musculoskele...

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Bibliographic Details
Published in:BMC musculoskeletal disorders 2011-11, Vol.12 (1), p.250-250, Article 250
Main Authors: Morii, Takeshi, Mochizuki, Kazuo, Tajima, Takashi, Ichimura, Shoichi, Satomi, Kazuhiko
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anticoagulants
Biomarkers, Tumor - blood
Blood proteins
Bone Neoplasms - blood
Bone Neoplasms - diagnosis
Bone Neoplasms - mortality
Bone surgery
Cancer
Cancer therapies
Child
Clinical medicine
Drug therapy
Female
Fibrin Fibrinogen Degradation Products - metabolism
Humans
Male
Measurement
Middle Aged
Multivariate analysis
Plasma
Prognosis
Protein Multimerization
Radiation therapy
Retrospective Studies
Risk Factors
Sarcoma
Sarcoma - blood
Sarcoma - diagnosis
Sarcoma - mortality
Soft Tissue Neoplasms - blood
Soft Tissue Neoplasms - diagnosis
Soft Tissue Neoplasms - mortality
Statistical analysis
Survival analysis
Vascular endothelial growth factor
Young Adult
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Summary:Plasma d-dimer levels have been associated with the status of tumor progression or oncological outcomes in cancer. Although there are many evidences suggesting the involvement of procoagulant trend in musculoskeletal sarcoma, no clinical data on d-dimer levels and oncological outcome of musculoskeletal sarcoma has been reported. In this study, we included a total of 85 patients who were diagnosed with musculoskeletal sarcoma and treated at our institute. Plasma d-dimer levels were determined before performing any clinical intervention, including open biopsy, chemotherapy, radiotherapy or tumor resection. We evaluated the effect of d-dimer levels and other clinicopathological factors on oncological outcomes of patients. Upregulation of plasma d-dimer levels proved to be an independent risk factor for metastasis and lethal outcome of patients with musculoskeletal sarcoma. Upregulation of plasma d-dimer levels were indicated poor oncological outcome in metastasis and total survival rate of musculoskeletal sarcoma patients. Hence d-dimer levels may be a helpful marker for evaluating the tumor progression status and prognosis of musculoskeletal sarcoma.
ISSN:1471-2474
1471-2474
DOI:10.1186/1471-2474-12-250