Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization?

Streptococcus pneumoniae remains an important human pathogen. For more than 100 years, there have been vaccine efforts to prevent pneumococcal infection. The pneumococcal conjugate vaccines have significantly reduced invasive disease. However, these vaccines have changed pneumococcal ecology within...

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Bibliographic Details
Published in:mBio 2016-05, Vol.7 (3)
Main Authors: McDaniel, Larry S, Swiatlo, Edwin
Format: Article
Language:English
Subjects:
Carrier State - microbiology
Carrier State - prevention & control
Humans
Infant
Nasopharynx - microbiology
Pneumococcal Infections - microbiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - immunology
Streptococcus pneumoniae - physiology
Vaccines, Conjugate
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Summary:Streptococcus pneumoniae remains an important human pathogen. For more than 100 years, there have been vaccine efforts to prevent pneumococcal infection. The pneumococcal conjugate vaccines have significantly reduced invasive disease. However, these vaccines have changed pneumococcal ecology within the human nasopharynx. We suggest that elimination of the pneumococcus from the human nasopharynx can have consequences that should be considered as the next generation of pneumococcal vaccines is developed.
ISSN:2161-2129
2150-7511
DOI:10.1128/mBio.00545-16