Corneal densitometry in Chinese adults with healthy corneas: associations with sex, age, ocular metrics, and optical characteristics

Standardized corneal densitometry (CD) values in large samples of healthy Chinese individuals are scarce. Therefore, we aimed to determine the standard CD values using a Scheimpflug camera in healthy corneas, investigate the correlations of sex, age, and ocular parameters with corneal density, and e...

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Bibliographic Details
Published in:BMC ophthalmology 2024-05, Vol.24 (1), p.230-8, Article 230
Main Authors: Ning, Jiliang, Sun, Siyu, Zhang, Qiaosi, Jin, Lin, Liu, Xiaoyu, Xu, Jun, Zhang, Lijun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age
Age Factors
Aged
Asian People
Axial length
Cameras
China
Cornea
Cornea - anatomy & histology
Cornea - diagnostic imaging
Corneal densitometry
Densitometry
East Asian People
Eye diseases
Female
Females
Generalized estimating equations
Healthy Volunteers
Humans
Light
Male
Males
Measurement techniques
Middle Aged
Ocular parameters
Optical properties
Reference Values
Retrospective Studies
Sex
Sex differences
Sex Factors
Sexes
Software
Statistical analysis
Young Adult
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Summary:Standardized corneal densitometry (CD) values in large samples of healthy Chinese individuals are scarce. Therefore, we aimed to determine the standard CD values using a Scheimpflug camera in healthy corneas, investigate the correlations of sex, age, and ocular parameters with corneal density, and explore the impact of corneal density on the forward scattering and optical quality of the eye. This retrospective observational study involved 990 healthy Chinese individuals, including 494 males and 496 females (mean age: 23.88 ± 6.90 years). The CD values at various depths and radial areas of 0-12 mm were measured using a Scheimpflug camera. Densitometric measurements were expressed in standardized grayscale units (GSU). The optical scatter index (OSI), modulation transfer function cutoff values (MTF ), and Strehl's ratio (SR) were also determined using an optical quality analysis system. The average CD within a 12 mm diameter area was 16.26 ± 1.35 GSU. The highest and lowest optical densities at different depths were observed in the anterior (21.41 ± 2.16 GSU) and posterior (12.00 ± 1.01 GSU) layers, respectively (P 
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-024-03500-y