Correlation between antibiotic consumption and the incidence of healthcare facility-onset Clostridioides difficile infection: a retrospective chart review and analysis

• Published in: Antimicrobial resistance & infection control 2021-08, Vol.10 (1), p.117-117, Article 117
• Main Authors: Yun, Ji Hyun, Park, Ga Eun, Ki, Hyun Kyun
• Format: Article
• Language: English
• Subjects: Analysis; Anti-Bacterial Agents - administration & dosage; Antibacterial agents; Antibiotics; Antimicrobial Stewardship; Beta lactamases; beta-Lactamase Inhibitors - administration & dosage; Clostridium Infections - epidemiology; Consumption; Consumption data; Correlation; Cross Infection - epidemiology; Diarrhea; Disease control; Drug resistance; Drug Utilization Review; Health aspects; Health care; Health facilities; Healthcare facility-onset Clostridium difficile infection; Hospitals; Humans; Incidence; Infection; Infections; Infectious diseases; Inhibitors; Medical centers; Medical research; Medicine, Experimental; Mortality; Patients; Regression analysis; Republic of Korea; Retrospective Studies; Risk factors; Tertiary Care Centers; Trends
• ISSN: 2047-2994; 2047-2994
• DOI: 10.1186/s13756-021-00986-9

Healthcare facility-onset Clostridioides difficile infection is the leading cause of antibiotic-associated diarrhea, and is associated with morbidity and mortality. The use of antibiotics is an important risk factor for healthcare facility-onset C. difficile infection. We evaluated the correlation between the incidence of healthcare facility-onset C. difficile infection and antibiotic consumption, according to antibiotic class. Patients with healthcare facility-onset C. difficile infection from January 2017 to December 2018 at Konkuk University Medical Center (a tertiary medical center) were included. We evaluated changes in the incidence of healthcare facility-onset C. difficile infection and antibiotic consumption. The correlation between the incidence of healthcare facility-onset C. difficile infection and antibiotic consumption was evaluated two ways: without a time interval and with 1-month interval matching. A total of 446 episodes of healthcare facility-onset C. difficile infection occurred during the study period. The incidence of healthcare facility-onset C. difficile infection was 9.3 episodes per 10,000 patient-days, and increased significantly. We observed an increase in the consumption of β-lactam/β-lactamase inhibitors, and a decrease in the consumption of other classes of antibiotics, with a significant decrease in the consumption of fluoroquinolones, glycopeptides, and clindamycin (P = 0.01, P