Are non-high-density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study

Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). To evaluate the association between non-HDL-C MetS and determine t...

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Published in:Lipids in health and disease 2018-11, Vol.17 (1), p.257-257, Article 257
Main Authors: Angoorani, Pooneh, Khademian, Majid, Ejtahed, Hanieh-Sadat, Heshmat, Ramin, Motlagh, Mohammad Esmaeil, Vafaeenia, Mahya, Shafiee, Gita, Mahdivi-Gorabi, Armita, Qorbani, Mostafa, Kelishadi, Roya
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adults
Age
Analysis
Arteriosclerosis
Atherosclerosis
Biomarkers - blood
Blood pressure
Cardiovascular system
Child
Children
Cholesterol
Cholesterol, LDL - blood
Cholesterol, VLDL - blood
Chronic illnesses
Diabetes
Dyslipidemia
Female
Health aspects
High density lipoprotein
Humans
Iran
Lipids
Lipoproteins
Low density lipoprotein
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic syndrome X
Non-high-density lipoprotein cholesterol
Obesity
Pediatrics
Sensitivity and Specificity
Studies
Surveillance
Systematic review
Teenagers
Triglycerides
Youth
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Summary:Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7-18 years. MetS was defined by the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group. The analysis of receiver operating characteristic (ROC) curve was applied to determine the optimal cut-points of non-HDL-C, difference between non-HDL-C and LDL-C (Diff-C) and triglycerides (TG) to HDL-C ratio (TG/HDL-C) for the prediction of MetS. Overall, the study participants consisted of 3843 students (52.3% boys) with mean (±SD) age of 12.28 (3.1) years. The odds of high LDL-C, low HDL-C and MetS were increased in subjects with higher non-HDL-C, Diff-C and TG/HDL-C (P 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-018-0895-1