Serum cytokines in patients with Brazilian pemphigus foliaceus (fogo selvagem)

Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a cont...

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Published in:Brazilian journal of medical and biological research 2000-09, Vol.33 (9), p.1065-1068
Main Authors: Zeoti, D M, Figueiredo, J F, Chiossi, M P, Roselino, A M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
BIOLOGY
bullous dermatoses
Case-Control Studies
Child
cytokines
Cytokines - blood
Enzyme-Linked Immunosorbent Assay
Female
fogo selvagem
Humans
Interferon-gamma - blood
Interleukins - blood
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Middle Aged
pemphigus
Pemphigus - blood
Pemphigus - immunology
pemphigus foliaceus
Statistics, Nonparametric
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container_issue 9
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creator Zeoti, D M
Figueiredo, J F
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description Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a control group consisting of 10 healthy individuals were studied. Serum IL-2, IL-4, IL-5, IL-10, IL-12 and IFN-gamma were measured in the two groups by ELISA. The median concentration of IL-2 was lower in PF patients compared to the control group (0.45 and 9.50 pg/ml, respectively), as also was the concentration of IL-4 (0.26 and 10.16 pg/ml, respectively). The same was observed for IL-5 (7.94 and 15.74 pg/ml, respectively) and for IFN-gamma (5.90 and 8.58 pg/ml, respectively). For IL-10 and IL-12, higher concentrations were observed in PF compared to the control group (IL-10: 24.76 and 20.92; IL-12: 2.92 and 1.17 pg/ml, respectively). Considering the Th1/Th2 paradigm, it seems that a Th2 profile, mainly represented by IL-10, predominates in PF.
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ispartof Brazilian journal of medical and biological research, 2000-09, Vol.33 (9), p.1065-1068
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source SciELO Brazil; IngentaConnect Journals
subjects Adolescent
Adult
Aged
BIOLOGY
bullous dermatoses
Case-Control Studies
Child
cytokines
Cytokines - blood
Enzyme-Linked Immunosorbent Assay
Female
fogo selvagem
Humans
Interferon-gamma - blood
Interleukins - blood
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Middle Aged
pemphigus
Pemphigus - blood
Pemphigus - immunology
pemphigus foliaceus
Statistics, Nonparametric
title Serum cytokines in patients with Brazilian pemphigus foliaceus (fogo selvagem)
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