Highly oxygenated cyclohexenes from the leaves of Uvaria grandiflora Roxb. ex Hornem and their cytotoxic and α-glucosidase inhibitory activities

Phytochemical investigation of the leaf extract of Uvaria grandiflora Roxb. ex Hornem led to the isolation and identification of two new highly oxygenated cyclohexenes, uvariagrandols A (1) and B (2), together with seven known compounds (3–9). Their structures were elucidated by spectroscopic method...

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Bibliographic Details
Published in:Heliyon 2025-01, Vol.11 (1), p.e41326
Main Authors: Virayu Suthiphasilp, Moses Egoh Betangah, Passakorn Teerapongpisan, Narawadee Rujanapun, Boonyanoot Chaiyosang, Sarawut Tontapha, Pakit Kumboonma, Brian O. Patrick, Raymond J. Andersen, Rawiwan Charoensup, Thidarat Duangyod, Phunrawie Promnart, Tharakorn Maneerat, Surat Laphookhieo
Format: Article
Language:English
Subjects:
Annonaceae
Cytotoxicity
Highly oxygenated cyclohexenes
Uvaria grandiflora
α-Glucosidase inhibitory activity
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Summary:Phytochemical investigation of the leaf extract of Uvaria grandiflora Roxb. ex Hornem led to the isolation and identification of two new highly oxygenated cyclohexenes, uvariagrandols A (1) and B (2), together with seven known compounds (3–9). Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. The (1S,2S,3R,6S) absolute configuration of uvariagrandols A and B was established by the comparison of the experimental and calculated electronic circular dichroism (ECD). (+)-Grandifloracin (9) displayed cytotoxicity against SW480 and K562 cell lines with IC50 values of 154.9 and 60.9 μM, respectively. 6-Methoxyzeylenol (5) had α-glucosidase inhibitory activity with the IC50 value of 34.1 μM.
ISSN:2405-8440