Perspectives of Vaccination in Chagas Disease Revisited

The perspectives for a Chagas Disease vaccine 30 years ago and today are compared. Antigens and adjuvants have improved, but logistic problems remain the same. Sterilizing vaccines have not been produced and animal models for chronic Chagas have not been developed. Vector control has been successful...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2009-07, Vol.104 (suppl 1), p.275-280
Main Author: Camargo, Erney Plessmann
Format: Article
Language:English
Subjects:
animal models
Animals
Chagas Disease - prevention & control
epidemiological targets
Humans
Models, Animal
PARASITOLOGY
Protozoan Vaccines - immunology
Recombinant Proteins - immunology
recombinant vaccines
TROPICAL MEDICINE
Trypanosoma cruzi - immunology
vaccines
vaccines - animal models - vector control - epidemiological targets - recombinant vaccines
Vaccines, DNA - immunology
vector control
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Summary:The perspectives for a Chagas Disease vaccine 30 years ago and today are compared. Antigens and adjuvants have improved, but logistic problems remain the same. Sterilizing vaccines have not been produced and animal models for chronic Chagas have not been developed. Vector control has been successful and Chagas incidence has come to a halt. We do not have a population candidate to vaccination now in Brazil. And if we had, we would not know how to evaluate the success of vaccination in a short time period. A vaccine may not seem important at the moment. However, scientific reasons and incertitudes about the future recommend that a search for a vaccine be continued.
ISSN:1678-8060
0074-0276
1678-8060
0074-0276
DOI:10.1590/S0074-02762009000900036