Multidrug-Resistant Tuberculosis In A Referral Center In Rome: 2011- 2016

Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in low incidence countries in Europe. The aim of this study was to attempt to have a better insight into the trends of MDR-TB in the metropolitan area of Rome, within the Italian and the foreign-born population, based on mi...

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Bibliographic Details
Published in:Infection and drug resistance 2019-10, Vol.12, p.3275-3281
Main Authors: Cannas, A, Butera, O, Gualano, G, Parracino, M P, Venditti, C, Mazzarelli, A, Palmieri, F, Girardi, E, Di Caro, A
Format: Article
Language:English
Subjects:
Automation
Disease prevention
Drug resistance
Drug-susceptibility testing
Epidemiology
Hospitals
Immigrants
Infectious diseases
MDR-TB
Medical research
Microbial drug resistance
Microbiology
Migration
Multidrug resistance
Multidrug resistant organisms
Original Research
Patients
Population
Public health
Public health movements
Trends
Tuberculosis
XDR-TB
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Summary:Multidrug-resistant tuberculosis (MDR-TB) is a major burden to public health in low incidence countries in Europe. The aim of this study was to attempt to have a better insight into the trends of MDR-TB in the metropolitan area of Rome, within the Italian and the foreign-born population, based on microbiological and demographic data. We performed a prospective study, collecting microbiological data based on phenotypic drug-resistant testing (DST) of TB strains consecutively isolated in a referral hospital in Rome, the capital city of a low TB incidence country, over a 6-year period, and correlated them to the geographical origin of patients. This study was carried out in a referral hospital for patients with drug-resistant TB from the whole region. Drug-resistance data from 926 patients with a microbiological diagnosis of TB from 2011 to 2016 show a 5.5% rate of MDR-TB, mostly occurring in patients born in a single East European country, that has a high incidence of MDR-TB. The strains isolated from these patients frequently carry additional resistances, leading to an increased risk of developing extensively drug-resistant (XDR) TB. In the great metropolitan area of Rome, MDR-TB more frequently occurs in patients who were born in a single country from Eastern Europe known to have high rates of MDR-TB and long-time residents in Italy. Recent immigrants from non-European countries do not appear to contribute to the rates of MDR-TB reported in this article. This knowledge of local TB trends could help improve the measures of surveillance and prevention of disease.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S218744