Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue

Studying transport processes in the brain’s extracellular space is a complicated problem when considering the brain’s tissue. Tests of corresponding physical and mathematical problems, as well as the need for materials with cheap but realistic properties to allow for testing of drug delivery systems...

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Bibliographic Details
Published in:Fluids (Basel) 2023-05, Vol.8 (6), p.167
Main Authors: Vanina, Anastasia S, Sychev, Alexander V, Lavrova, Anastasia I, Gavrilov, Pavel V, Andropova, Polina L, Grekhnyova, Elena V, Kudryavtseva, Tatiana N, Postnikov, Eugene B
Format: Article
Language:English
Subjects:
Additives
Brain
brain’s parenchyma phantom
Collagen
Computed tomography
Contrast agents
CT imaging
diffusion
Diffusion coefficient
Drug delivery systems
Drugs
fluid flow
Glycerol
hydrogel
Hydrogels
Lipids
Partial differential equations
Permeability
Physiological aspects
Surfactants
Tissues
Tomography
Transport processes
Vehicles
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Summary:Studying transport processes in the brain’s extracellular space is a complicated problem when considering the brain’s tissue. Tests of corresponding physical and mathematical problems, as well as the need for materials with cheap but realistic properties to allow for testing of drug delivery systems, lead to the development of artificial phantom media, one kind of which is explored in this work. We report results from quantifying the spread of a standard contrast agent used in clinical computed tomography, Iopromide, in samples of collagen-based hydrogels. Its pure variant as well as samples supplied with lipid and surfactant additives were explored. By comparing to solutions of the diffusion equation which reproduce these data, the respective diffusion coefficients were determined. It was shown that they are relevant to the range typical for living tissue, grow with elevation in the lipid content and diminish with growth in surfactant concentration.
ISSN:2311-5521
2311-5521
DOI:10.3390/fluids8060167