Pharmacological treatment of actinic keratosis

Actinic keratosis (AK) is a disease characterized by hyperkeratotic lesions on skin damaged by ultraviolet. radiation. These lesions may progress to squamous cell or basal cell carcinoma. Currently pharmacotherapy and different surgical procedures are used in AK therapy. The most common treatment op...

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Bibliographic Details
Published in:Przegląd dermatologiczny 2016-01, Vol.4 (4), p.330-336
Main Authors: Zwierzyńska, Ewa, Zawistowska, Anna, Pietrzak, Bogusława
Format: Article
Language:eng ; pol
Subjects:
actinic keratosis
clinical studies
pharmacotherapy
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Description
Summary:Actinic keratosis (AK) is a disease characterized by hyperkeratotic lesions on skin damaged by ultraviolet. radiation. These lesions may progress to squamous cell or basal cell carcinoma. Currently pharmacotherapy and different surgical procedures are used in AK therapy. The most common treatment options are 5-fluorouracil, imiquimod, diclofenac, ingenol mebutate, and first and third generation retinoids (retinol, adapalene, tazarotene). Furthermore, research is being carried out in order to test new medications including nicotinamide, resiquimod, piroxicam, potassium dobesilate and oleogel based on a triterpene extract (betulin, betulinic acid). Recently, the preventive effect of acetylsalicylic acid and celecoxib has also been investigated.
ISSN:0033-2526
2084-9893
DOI:10.5114/dr.2016.61784