Impact of Toxoplasma gondii Infection on Host Non-coding RNA Responses

As an intracellular microbe, must establish a highly intimate relationship with its host to ensure success as a parasite. Many studies over the last decade-and-a-half have highlighted how the host reshapes its immunoproteome to survive infection, and conversely how the parasite regulates host respon...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2019-05, Vol.9, p.132-132
Main Authors: Menard, Kayla L, Haskins, Breanne E, Denkers, Eric Y
Format: Article
Language:English
Subjects:
Cellular and Infection Microbiology
Gene Expression Regulation
Host-Pathogen Interactions
Humans
lncRNA
long non-coding RNA
microRNA
miRNA
non-coding RNA
RNA, Untranslated - biosynthesis
Toxoplasma - growth & development
Toxoplasma - immunology
Toxoplasma gondii
Toxoplasmosis - immunology
Toxoplasmosis - pathology
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Summary:As an intracellular microbe, must establish a highly intimate relationship with its host to ensure success as a parasite. Many studies over the last decade-and-a-half have highlighted how the host reshapes its immunoproteome to survive infection, and conversely how the parasite regulates host responses to ensure persistence. The role of host non-protein-coding RNA during infection is a vast and largely unexplored area of emerging interest. The potential importance of this facet of the host-parasite interaction is underscored by current estimates that as much as 80% of the host genome is transcribed into non-translated RNA. Here, we review the current state of knowledge with respect to two major classes of non-coding RNA, microRNA (miRNA) and long non-coding RNA (lncRNA), in the host response to infection. These two classes of regulatory RNA are known to have profound and widespread effects on cell function. However, their impact on infection and immunity is not well-understood, particularly for the response to . Nevertheless, numerous miRNAs have been identified that are upregulated by , and emerging evidence suggests a functional role during infection. While the field of lncRNA is in its infancy, it is already clear that is also a strong trigger for this class of regulatory RNA. Non-coding RNA responses induced by are likely to be major determinants of the host's ability to resist infection and the parasite's ability to establish long-term latency.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2019.00132