Recent Trends in Electrochemical Sensors for Vital Biomedical Markers Using Hybrid Nanostructured Materials

• Published in: Advanced science 2020-07, Vol.7 (13), p.n/a
• Main Authors: Reddy, K. Koteshwara, Bandal, Harshad, Satyanarayana, Moru, Goud, Kotagiri Yugender, Gobi, Kauveri Vengatajalabathy, Jayaramudu, Tippabattini, Amalraj, John, Kim, Hern
• Format: Article
• Language: English
• Subjects: Biomarkers; electrochemical biosensors; Heart attacks; hybrid nanocomposites; hybrid nanostructures; Nanomaterials; recognition elements; Review; Sensors
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.201902980

This work provides a succinct insight into the recent developments in electrochemical quantification of vital biomedical markers using hybrid metallic composite nanostructures. After a brief introduction to the biomarkers, five types of crucial biomarkers, which require timely and periodical monitoring, are shortlisted, namely, cancer, cardiac, inflammatory, diabetic and renal biomarkers. This review emphasizes the usage and advantages of hybrid nanostructured materials as the recognition matrices toward the detection of vital biomarkers. Different transduction methods (fluorescence, electrophoresis, chemiluminescence, electrochemiluminescence, surface plasmon resonance, surface‐enhanced Raman spectroscopy) reported for the biomarkers are discussed comprehensively to present an overview of the current research works. Recent advancements in the electrochemical (amperometric, voltammetric, and impedimetric) sensor systems constructed with metal nanoparticle‐derived hybrid composite nanostructures toward the selective detection of chosen vital biomarkers are specifically analyzed. It describes the challenges involved and the strategies reported for the development of selective, sensitive, and disposable electrochemical biosensors with the details of fabrication, functionalization, and applications of hybrid metallic composite nanostructures. Biomarkers indicate the physiological state of a disease. Accurate and selective measurement of such biomarkers in physiological body fluids is the most prerequisite in the healthcare sector. This review emphasizes the hybrid metallic composite nanostructure‐based electrochemical sensors for five types of crucial biomedical markers relevant to the most acute diseases namely, cancer, cardiac, inflammatory, diabetic, and renal biomarkers.