Curbing Inflammation

[...]an original paper compared the immunosuppressive properties of statins on T-cell immune responses with other conventional immunosuppressive agents, such as cyclosporine or dexamethasone (A. Jameel et al.). The paper demonstrated differential immunosuppressive properties of statins on T-cell pro...

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Bibliographic Details
Published in:International journal of inflammation 2013-01, Vol.2013 (2013), p.1-3
Main Authors: Landis, Robert Clive, Buckley, Christopher D., Evora, Paulo Roberto Barbosa, Hart, David A.
Format: Article
Language:English
Subjects:
Blood
Cardiovascular disease
Care and treatment
Cellular signal transduction
Critical care
Cytokines
Heart surgery
Inflammation
Inflammatory diseases
Kinases
Medical research
Patients
Permeability
Physiological aspects
Proteins
Sepsis
Surgical outcomes
Thoracic surgery
Tumor necrosis factor-TNF
Wound healing
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Summary:[...]an original paper compared the immunosuppressive properties of statins on T-cell immune responses with other conventional immunosuppressive agents, such as cyclosporine or dexamethasone (A. Jameel et al.). The paper demonstrated differential immunosuppressive properties of statins on T-cell proliferation, IL-1β, IL-17, and interferon- (IFN-) γ production depending on the type of immune activation. 4. CD163+ cells were associated in the second paper with the phagocytic removal of apoptotic neutrophils, hence limiting potential histotoxic injury, with a shifting of the cytokine profile from proinflammatory mediators, including TNF-α, IL-6, IL-8/CXCL8, monocyte chemoattractant protein (MCP-1/CCL2), macrophage inflammatory protein (MIP1α/CCL3), MIP-1β/CCL4, and eotaxin (CCL11), towards immunoregulatory mediators, including macrophage-derived chemokine (MDC/CCL22), interferon-inducible protein (IP-10/CXCL10), and transforming growth factor (TGF)-β. [...]an interesting review of proresolving mediators highlights the promise of melanocortin peptides as agents to limit the inflammatory process and protect tissues in a variety of preclinical models for inflammatory disease. 5.
ISSN:2090-8040
2042-0099
2042-0099
DOI:10.1155/2013/468287