Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

[Display omitted] •Type 2 diabetes predisposes to early ageing of the brain.•Hippocampal atrophy and mitochondrial dysfunction lead to cognitive decline.•Dietary fibres are fermented in the gut producing short chain fatty acids that improve mitochondrial function.•Gum Arabic fibre prevents cognitive...

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Bibliographic Details
Published in:Journal of functional foods 2021-12, Vol.87, p.104757, Article 104757
Main Authors: Rajab, Ebrahim, Keogh, Michael B., Laiva, Ashang L., Al Hannan, Fatima, Fateel, Maryam, Abdulwahab, Fatema, Al Madhoob, Fatema, AlHamer, Bassam, Ghazzal, Samar Y., Dawaishan, Abdulla, Mahdi, Sadiq, Qareeballa, Abdulrahman, Almosawi, Sayed M., Falamarzi, Faisal, ElMusharaf, Khalifa, Kamal, Amer
Format: Article
Language:English
Subjects:
Diabetes
Gum Arabic
Hippocampus
Memory
Mitochondria
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Summary:[Display omitted] •Type 2 diabetes predisposes to early ageing of the brain.•Hippocampal atrophy and mitochondrial dysfunction lead to cognitive decline.•Dietary fibres are fermented in the gut producing short chain fatty acids that improve mitochondrial function.•Gum Arabic fibre prevents cognitive decline, improves mitochondrial function in type 2 diabetes. The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2021.104757