Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

[Display omitted] •Type 2 diabetes predisposes to early ageing of the brain.•Hippocampal atrophy and mitochondrial dysfunction lead to cognitive decline.•Dietary fibres are fermented in the gut producing short chain fatty acids that improve mitochondrial function.•Gum Arabic fibre prevents cognitive...

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Published in:Journal of functional foods 2021-12, Vol.87, p.104757, Article 104757
Main Authors: Rajab, Ebrahim, Keogh, Michael B., Laiva, Ashang L., Al Hannan, Fatima, Fateel, Maryam, Abdulwahab, Fatema, Al Madhoob, Fatema, AlHamer, Bassam, Ghazzal, Samar Y., Dawaishan, Abdulla, Mahdi, Sadiq, Qareeballa, Abdulrahman, Almosawi, Sayed M., Falamarzi, Faisal, ElMusharaf, Khalifa, Kamal, Amer
Format: Article
Language:English
Subjects:
Diabetes
Gum Arabic
Hippocampus
Memory
Mitochondria
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cited_by cdi_FETCH-LOGICAL-c406t-e750bad595f4a15d3a20be9c45b109c9e7b905fb9a73e7ce1fce8514ba220bcc3
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container_title Journal of functional foods
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creator Rajab, Ebrahim
Keogh, Michael B.
Laiva, Ashang L.
Al Hannan, Fatima
Fateel, Maryam
Abdulwahab, Fatema
Al Madhoob, Fatema
AlHamer, Bassam
Ghazzal, Samar Y.
Dawaishan, Abdulla
Mahdi, Sadiq
Qareeballa, Abdulrahman
Almosawi, Sayed M.
Falamarzi, Faisal
ElMusharaf, Khalifa
Kamal, Amer
description [Display omitted] •Type 2 diabetes predisposes to early ageing of the brain.•Hippocampal atrophy and mitochondrial dysfunction lead to cognitive decline.•Dietary fibres are fermented in the gut producing short chain fatty acids that improve mitochondrial function.•Gum Arabic fibre prevents cognitive decline, improves mitochondrial function in type 2 diabetes. The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in water maze was shorter for Diabetes + GA compared to Diabetes + Water (P 
doi_str_mv 10.1016/j.jff.2021.104757
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source Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)
subjects Diabetes
Gum Arabic
Hippocampus
Memory
Mitochondria
title Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
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