The efficacy of autologous matrix-induced chondrogenesis (AMIC) for osteochondral lesions of the talus in the mid-long term: a systematic review and meta-analysis

The objective of this study was to provide a comprehensive review of the existing literature regarding the treatment of osteochondral lesions of the talus (OLT) using autologous matrix-induced chondrogenesis (AMIC), while also discussing the mid-long term functional outcomes, complications, and surg...

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Bibliographic Details
Published in:Journal of orthopaedic surgery and research 2024-06, Vol.19 (1), p.373-12, Article 373
Main Authors: Jiang, Ning, Li, Haomin, Wang, Jia, Shen, Lin, Zeng, Xiantie
Format: Article
Language:English
Subjects:
AMIC
Autologous matrix-induced chondrogenesis
Care and treatment
Cartilage, Articular - surgery
Chondrogenesis - physiology
Humans
Meta-analysis
Osteochondral lesions of the talus
Pain
Systematic Review
Talus - surgery
Time Factors
Transplantation, Autologous - methods
Treatment Outcome
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Summary:The objective of this study was to provide a comprehensive review of the existing literature regarding the treatment of osteochondral lesions of the talus (OLT) using autologous matrix-induced chondrogenesis (AMIC), while also discussing the mid-long term functional outcomes, complications, and surgical failure rate. We searched Embase, PubMed, and Web of Science for studies on OLT treated with AMIC with an average follow-up of at least 2 years. Publication information, patient data, functional scores, surgical failure rate, and complications were extracted. A total of 15 studies were screened and included, with 12 case series selected for meta-analysis and 3 non-randomized controlled studies chosen for descriptive analysis. The improvements in the Visual Analog Scale (VAS), the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot, and Tegner scores at the last follow-up were (SMD = - 2.825, 95% CI - 3.343 to  - 2.306, P 
ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-024-04864-z