In Vitro and Human Pilot Studies of Different Topical Formulations Containing Rosa Species for the Treatment of Psoriasis

The aim of this study was to evaluate the phytochemical profile and antioxidant properties of the extracts from three Rosa species (R. canina, R. damascena, R. cairo), to develop and investigate topical formulations with lyophilized forms of extracts for the treatment of psoriasis. Phytochemical scr...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-08, Vol.27 (17), p.5499
Main Authors: Gavra, Diana Ioana, Endres, Laura, Pető, Ágota, Józsa, Liza, Fehér, Pálma, Ujhelyi, Zoltán, Pallag, Annamária, Marian, Eleonora, Vicas, Laura Gratiela, Ghitea, Timea Claudia, Muresan, Mariana, Bácskay, Ildikó, Jurca, Tünde
Format: Article
Language:English
Subjects:
Acids
antioxidant capacity
Antioxidants
bioactive compounds
Biocompatibility
Drug delivery
Drug delivery systems
Erythema
Evaluation
Flavonoids
Health services
human clinical study
Nanoemulsions
Nanoparticles
Patients
Phenolic compounds
Phenols
phytochemical profile
Polyphenols
Psoriasis
Quality of life
Skin
Skin diseases
Surfactants
topical formulation
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Summary:The aim of this study was to evaluate the phytochemical profile and antioxidant properties of the extracts from three Rosa species (R. canina, R. damascena, R. cairo), to develop and investigate topical formulations with lyophilized forms of extracts for the treatment of psoriasis. Phytochemical screening and in vitro total antioxidant capacity (DPPH, FRAP, CUPRAC, SOD) of studied samples were examined and compared. Lyophilized extracts of roses were dissolved in Transcutol HP and different formulations of creams were prepared. Franz diffusion method was used to evaluate the drug release and biocompatibility was tested on HaCaT cells. Rosa damascene had the best results regarding all the analyses that were conducted. After the evaluation of topical products, the formulation with Rosa damascena extract in a self-emulsifying drug delivery system was tested on a human clinical study that involved 20 patients. At the end of the clinical study an improvement in the quality of life of the patients was observed and erythema, induration and scaling were reduced. The present study indicates that our examined extracts exhibited great phenolic content, antioxidant capacity and safety profile of topical formulation and therefore can be used as a reliable source of natural antioxidants and may be used as a complementary treatment to improve the quality life of patients with psoriasis or may be tested on another diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27175499