Reductive prodrug and AIE copolymer nanoparticle for monitoring and chemotherapy

Polymeric micelle systems for drug delivery, monitor and chemotherapy have gained significant attention, and reductive polymeric micelle systems have become particularly attractive due to their controlled release behavior without additional assistance. However, there are challenges in accurately con...

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Bibliographic Details
Published in:BMC cancer 2024-03, Vol.24 (1), p.382-382, Article 382
Main Authors: Wang, Zigui, Li, Guilin, Zhao, Qiaohui, Fu, Guangyu, Yang, Zengli, Zhang, Guojun
Format: Article
Language:English
Subjects:
AIE
Biodistribution
Cancer
Cancer therapies
Cellulose
Chemical bonds
Chemotherapy
Contrast agents
Contrast media
Controlled release
Drug delivery
Drug delivery systems
Drugs
Electron microscopes
Health aspects
Methods
Micelles
Microenvironments
Molecular weight
Nanoparticles
Platinum
Polymerization
Polymers
Prodrugs
Properties
Real-time tracing
Toxicity
Vehicles
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Summary:Polymeric micelle systems for drug delivery, monitor and chemotherapy have gained significant attention, and reductive polymeric micelle systems have become particularly attractive due to their controlled release behavior without additional assistance. However, there are challenges in accurately controlling drug and probe release from the nanoparticles and determining the loading content of drug and probe. To address these issues, we have developed a reduction-responsive Pt(IV) prodrug-based polymeric delivery system that can be dynamically monitored using aggregation-induced emission luminogens (AIE) based bioprobes. These polymeric micelle can self-assemble into nanoparticles and release both bio-active Pt(II) drug and bio-probe upon reduction activation. TPE molecules released in the inner endo/lysosomal microenvironment aggregate and fluoresce upon irradiation, thus allowing real-time tracking of drug biodistribution without additional contrast agents. Advantages of this system include position-specific chemical bond cleavage, control of platinum content, and monitoring of drug reduction and biodistribution.
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-12135-7