Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials. Therefor...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.11751-11751, Article 11751
Main Authors: Nazmuddin, Muhammad, Philippens, Ingrid H. C. H. M., van Laar, Teus
Format: Article
Language:English
Subjects:
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Acetylcholine
Alzheimer's disease
Animal research
Blood flow
Cerebral blood flow
Clinical trials
Cognition
Deep brain stimulation
Dementia disorders
Electrical stimuli
Humanities and Social Sciences
Lewy bodies
multidisciplinary
Neurodegenerative diseases
Neuroplasticity
Neuroprotection
Nucleus basalis
Science
Science (multidisciplinary)
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Summary:Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been clinically investigated in Alzheimer’s disease (AD) and Lewy body dementia (LBD). However, the clinical effects are highly variable, which questions the suggested basic principles underlying these clinical trials. Therefore, preclinical and clinical data on the design of NBM stimulation experiments and its effects on behavioral and neurophysiological aspects are systematically reviewed here. Animal studies have shown that electrical stimulation of the NBM enhanced cognition, increased the release of acetylcholine, enhanced cerebral blood flow, released several neuroprotective factors, and facilitates plasticity of cortical and subcortical receptive fields. However, the translation of these outcomes to current clinical practice is hampered by the fact that mainly animals with an intact NBM were used, whereas most animals were stimulated unilaterally, with different stimulation paradigms for only restricted timeframes. Future animal research has to refine the NBM stimulation methods, using partially lesioned NBM nuclei, to better resemble the clinical situation in AD, and LBD. More preclinical data on the effect of stimulation of lesioned NBM should be present, before DBS of the NBM in human is explored further.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91391-0