A standardized herbal combination of Astragalus membranaceus and Paeonia japonica promotes skeletal muscle hypertrophy in a treadmill exercise mouse model

Maintaining a normal range of muscle mass and function is crucial not only for sustaining a healthy life but also for preventing various disorders. Numerous nutritional or natural resources are being explored for their potential muscle hypertrophic properties. We aimed to evaluate the muscle hypertr...

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Bibliographic Details
Published in:Frontiers in nutrition (Lausanne) 2024-06, Vol.11, p.1362550
Main Authors: Lee, Sung-Bae, Woo, Tae-Wook, Baek, Dong-Cheol, Son, Chang-Gue
Format: Article
Language:English
Subjects:
Astragalus membranaceus
exercise
hypertrophy
Nutrition
Paeonia japonica
skeletal muscle
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Summary:Maintaining a normal range of muscle mass and function is crucial not only for sustaining a healthy life but also for preventing various disorders. Numerous nutritional or natural resources are being explored for their potential muscle hypertrophic properties. We aimed to evaluate the muscle hypertrophic effects of APX, a 1:1 mixture of and . In addition to the myotube differentiation cell assay, we utilized a weighted exercise-based animal model and evaluated changes in muscle hypertrophy using dual-energy X-ray absorptiometry (DXA) and histological analysis. The 8-week treadmill exercise led to notable decreases in body weight and fat mass but an increase in muscle mass compared to the control group. Administration of APX significantly accelerated muscle mass gain (   0.05) and rectus femoris (  
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2024.1362550