Biophysical Insights into Cancer Transformation and Treatment

Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-11
Main Authors: Tuszyński, Jack A., Čoček, Aleš, Nedbalová, Martina, Vrba, Jan, Jandová, Anna, Kobilková, Jitka, Foletti, Alberto, Pokorný, Jiří, Danani, Andrea
Format: Article
Language:English
Subjects:
Animals
Biophysics
Brain research
Cancer
Care and treatment
Cell Transformation, Neoplastic - radiation effects
Charge distribution
Colleges & universities
Electric fields
Electromagnetic Fields
Energy
Energy conversion
Energy Transfer
Fibroblasts
Frequency spectrum
Humans
Mammals
Metabolites
Metastasis
Mitochondria
Mitochondria - radiation effects
Models, Biological
Neoplasms - physiopathology
Oncology, Experimental
Otolaryngology
Restoration
Review
Tracks (paths)
Transformations (mathematics)
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Summary:Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2013/195028