Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers

Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance. Thus, we need to define the downstream effectors of sex hormo...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-08, Vol.19 (9), p.2543
Main Authors: Cheng, Meng, Michalski, Stephanie, Kommagani, Ramakrishna
Format: Article
Language:English
Subjects:
androgen
Androgens
Animals
Binding sites
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell adhesion & migration
Cell proliferation
DNA methylation
Drug delivery
Drug resistance
Endometrium
Epigenetics
estrogen
Estrogens
Female
Gene expression
Gene Expression Regulation, Neoplastic
GREB1
Hormone replacement therapy
Hormones - metabolism
Humans
Medical prognosis
Metastasis
Neoplasm Proteins - chemistry
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Ovarian cancer
Physiology
Progesterone
Prostate cancer
Receptors, Cytoplasmic and Nuclear - metabolism
Receptors, Steroid - metabolism
Review
Sex hormones
Signal Transduction
steroid hormone
Steroids - metabolism
Structure-Activity Relationship
Translational Medical Research
Tumors
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Summary:Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance. Thus, we need to define the downstream effectors of sex hormones in order to develop new treatment strategies for these cancers. Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1). is an early estrogen-responsive gene, and its expression is correlated with estrogen levels in breast cancer patients. Additionally, GREB1 responds to androgen in prostate cancer cells, and can stimulate the proliferation of breast, ovarian, and prostate cancer cells. Recent studies have shown that GREB1 also responds to progesterone in human endometrial cells, suggesting that is a pan steroid-responsive gene. This mini-review examines evidence that GREB1 participates in several hormone-dependent cancers and could be targeted to treat these cancers.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19092543