The hierarchy of sugar catabolization in Lactococcus cremoris

The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate-typically growth on glucose-is associated with the repression of other carbohydrate utilization genes, but it is not clear to what...

Full description

Saved in:
Bibliographic Details
Published in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0224823-e0224823
Main Authors: Douwenga, Sieze, van Olst, Berdien, Boeren, Sjef, Luo, Yanzhang, Lai, Xin, Teusink, Bas, Vervoort, Jacques, Kleerebezem, Michiel, Bachmann, Herwig
Format: Article
Language:English
Subjects:
catabolism
catabolite repression
Lactococcus
proteome
Research Article
sugar transition
Systems Biology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-a457t-21f938f833d82713d103e97b52ce22267feb78dd23091f6fef393857d14775983
container_end_page e0224823
container_issue 6
container_start_page e0224823
container_title Microbiology spectrum
container_volume 11
creator Douwenga, Sieze
van Olst, Berdien
Boeren, Sjef
Luo, Yanzhang
Lai, Xin
Teusink, Bas
Vervoort, Jacques
Kleerebezem, Michiel
Bachmann, Herwig
description The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate-typically growth on glucose-is associated with the repression of other carbohydrate utilization genes, but it is not clear to what extent catabolite repression is exerted by other sugars. We investigated the hierarchy of sugar utilization after substrate transitions in . For this, we determined the proteome and carbohydrate utilization capacity after growth on different sugars. The results show that the preparedness of cells for the utilization of "slower" sugars is not strictly determined by the growth rate. The data point to individual proteins relevant for various sugar transitions and suggest that the evolutionary history of the organism might be responsible for deviations from a strictly growth rate-related sugar catabolization hierarchy.
doi_str_mv 10.1128/spectrum.02248-23
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_a1e0b7c5ea134db993acd08a84a5d4ae</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_a1e0b7c5ea134db993acd08a84a5d4ae</doaj_id><sourcerecordid>2883582310</sourcerecordid><originalsourceid>FETCH-LOGICAL-a457t-21f938f833d82713d103e97b52ce22267feb78dd23091f6fef393857d14775983</originalsourceid><addsrcrecordid>eNp9kcFq3DAQhkVoScI2D9BL8bEXb6SRZcmHUkpIm8BCL-lZjKXxrhbb2kp2IX36OtkkJJeeZpiZ_xtmfsY-Cr4WAsxlPpCb0jysOUBlSpAn7BxErUpeNfrdq_yMXeS855wLwRUoOGVnUhtjGlOfsy93Oyp2gRImt7svYlfkeYupcDhhG_vwF6cQxyKMxQbdFF10bs6FSzTEFPIH9r7DPtPFU1yxX9-v765uys3PH7dX3zYlVkpPJYiukaYzUnoDWkgvuKRGtwocAUCtO2q18R4kb0RXd9TJZV5pLyqtVWPkit0euT7i3h5SGDDd24jBPhZi2lpMU3A9WRTEW-0UoZCVb5tGovPcoKlQ-QppYX09sg5zO5B3NE4J-zfQt50x7Ow2_rGCa6F4rRbC5ydCir9nypMdQnbU9zhSnLMFY6QyIJcrV0wcR12KOSfqXvYIbh9stM822kcbLchFsz5qMA9g93FO4_Lb_wo-vb7oZcWzy_IfrLeqQw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2883582310</pqid></control><display><type>article</type><title>The hierarchy of sugar catabolization in Lactococcus cremoris</title><source>American Society for Microbiology Journals</source><source>PubMed Central</source><creator>Douwenga, Sieze ; van Olst, Berdien ; Boeren, Sjef ; Luo, Yanzhang ; Lai, Xin ; Teusink, Bas ; Vervoort, Jacques ; Kleerebezem, Michiel ; Bachmann, Herwig</creator><contributor>Re, Angela</contributor><creatorcontrib>Douwenga, Sieze ; van Olst, Berdien ; Boeren, Sjef ; Luo, Yanzhang ; Lai, Xin ; Teusink, Bas ; Vervoort, Jacques ; Kleerebezem, Michiel ; Bachmann, Herwig ; Re, Angela</creatorcontrib><description>The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate-typically growth on glucose-is associated with the repression of other carbohydrate utilization genes, but it is not clear to what extent catabolite repression is exerted by other sugars. We investigated the hierarchy of sugar utilization after substrate transitions in . For this, we determined the proteome and carbohydrate utilization capacity after growth on different sugars. The results show that the preparedness of cells for the utilization of "slower" sugars is not strictly determined by the growth rate. The data point to individual proteins relevant for various sugar transitions and suggest that the evolutionary history of the organism might be responsible for deviations from a strictly growth rate-related sugar catabolization hierarchy.</description><identifier>ISSN: 2165-0497</identifier><identifier>EISSN: 2165-0497</identifier><identifier>DOI: 10.1128/spectrum.02248-23</identifier><identifier>PMID: 37888986</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>catabolism ; catabolite repression ; Lactococcus ; proteome ; Research Article ; sugar transition ; Systems Biology</subject><ispartof>Microbiology spectrum, 2023-12, Vol.11 (6), p.e0224823-e0224823</ispartof><rights>Copyright © 2023 Douwenga et al.</rights><rights>Copyright © 2023 Douwenga et al. 2023 Douwenga et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a457t-21f938f833d82713d103e97b52ce22267feb78dd23091f6fef393857d14775983</cites><orcidid>0000-0003-3929-0423 ; 0000-0002-0847-8821 ; 0000-0001-8596-0171 ; 0000-0003-3604-7524 ; 0000-0002-8224-0993 ; 0000-0002-0091-5687 ; 0000-0001-8552-2235</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/spectrum.02248-23$$EPDF$$P50$$Gasm2$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/spectrum.02248-23$$EHTML$$P50$$Gasm2$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3188,27924,27925,52751,52752,52753,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37888986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Re, Angela</contributor><creatorcontrib>Douwenga, Sieze</creatorcontrib><creatorcontrib>van Olst, Berdien</creatorcontrib><creatorcontrib>Boeren, Sjef</creatorcontrib><creatorcontrib>Luo, Yanzhang</creatorcontrib><creatorcontrib>Lai, Xin</creatorcontrib><creatorcontrib>Teusink, Bas</creatorcontrib><creatorcontrib>Vervoort, Jacques</creatorcontrib><creatorcontrib>Kleerebezem, Michiel</creatorcontrib><creatorcontrib>Bachmann, Herwig</creatorcontrib><title>The hierarchy of sugar catabolization in Lactococcus cremoris</title><title>Microbiology spectrum</title><addtitle>Spectrum</addtitle><addtitle>Microbiol Spectr</addtitle><description>The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate-typically growth on glucose-is associated with the repression of other carbohydrate utilization genes, but it is not clear to what extent catabolite repression is exerted by other sugars. We investigated the hierarchy of sugar utilization after substrate transitions in . For this, we determined the proteome and carbohydrate utilization capacity after growth on different sugars. The results show that the preparedness of cells for the utilization of "slower" sugars is not strictly determined by the growth rate. The data point to individual proteins relevant for various sugar transitions and suggest that the evolutionary history of the organism might be responsible for deviations from a strictly growth rate-related sugar catabolization hierarchy.</description><subject>catabolism</subject><subject>catabolite repression</subject><subject>Lactococcus</subject><subject>proteome</subject><subject>Research Article</subject><subject>sugar transition</subject><subject>Systems Biology</subject><issn>2165-0497</issn><issn>2165-0497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kcFq3DAQhkVoScI2D9BL8bEXb6SRZcmHUkpIm8BCL-lZjKXxrhbb2kp2IX36OtkkJJeeZpiZ_xtmfsY-Cr4WAsxlPpCb0jysOUBlSpAn7BxErUpeNfrdq_yMXeS855wLwRUoOGVnUhtjGlOfsy93Oyp2gRImt7svYlfkeYupcDhhG_vwF6cQxyKMxQbdFF10bs6FSzTEFPIH9r7DPtPFU1yxX9-v765uys3PH7dX3zYlVkpPJYiukaYzUnoDWkgvuKRGtwocAUCtO2q18R4kb0RXd9TJZV5pLyqtVWPkit0euT7i3h5SGDDd24jBPhZi2lpMU3A9WRTEW-0UoZCVb5tGovPcoKlQ-QppYX09sg5zO5B3NE4J-zfQt50x7Ow2_rGCa6F4rRbC5ydCir9nypMdQnbU9zhSnLMFY6QyIJcrV0wcR12KOSfqXvYIbh9stM822kcbLchFsz5qMA9g93FO4_Lb_wo-vb7oZcWzy_IfrLeqQw</recordid><startdate>20231212</startdate><enddate>20231212</enddate><creator>Douwenga, Sieze</creator><creator>van Olst, Berdien</creator><creator>Boeren, Sjef</creator><creator>Luo, Yanzhang</creator><creator>Lai, Xin</creator><creator>Teusink, Bas</creator><creator>Vervoort, Jacques</creator><creator>Kleerebezem, Michiel</creator><creator>Bachmann, Herwig</creator><general>American Society for Microbiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3929-0423</orcidid><orcidid>https://orcid.org/0000-0002-0847-8821</orcidid><orcidid>https://orcid.org/0000-0001-8596-0171</orcidid><orcidid>https://orcid.org/0000-0003-3604-7524</orcidid><orcidid>https://orcid.org/0000-0002-8224-0993</orcidid><orcidid>https://orcid.org/0000-0002-0091-5687</orcidid><orcidid>https://orcid.org/0000-0001-8552-2235</orcidid></search><sort><creationdate>20231212</creationdate><title>The hierarchy of sugar catabolization in Lactococcus cremoris</title><author>Douwenga, Sieze ; van Olst, Berdien ; Boeren, Sjef ; Luo, Yanzhang ; Lai, Xin ; Teusink, Bas ; Vervoort, Jacques ; Kleerebezem, Michiel ; Bachmann, Herwig</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a457t-21f938f833d82713d103e97b52ce22267feb78dd23091f6fef393857d14775983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>catabolism</topic><topic>catabolite repression</topic><topic>Lactococcus</topic><topic>proteome</topic><topic>Research Article</topic><topic>sugar transition</topic><topic>Systems Biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Douwenga, Sieze</creatorcontrib><creatorcontrib>van Olst, Berdien</creatorcontrib><creatorcontrib>Boeren, Sjef</creatorcontrib><creatorcontrib>Luo, Yanzhang</creatorcontrib><creatorcontrib>Lai, Xin</creatorcontrib><creatorcontrib>Teusink, Bas</creatorcontrib><creatorcontrib>Vervoort, Jacques</creatorcontrib><creatorcontrib>Kleerebezem, Michiel</creatorcontrib><creatorcontrib>Bachmann, Herwig</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Microbiology spectrum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Douwenga, Sieze</au><au>van Olst, Berdien</au><au>Boeren, Sjef</au><au>Luo, Yanzhang</au><au>Lai, Xin</au><au>Teusink, Bas</au><au>Vervoort, Jacques</au><au>Kleerebezem, Michiel</au><au>Bachmann, Herwig</au><au>Re, Angela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The hierarchy of sugar catabolization in Lactococcus cremoris</atitle><jtitle>Microbiology spectrum</jtitle><stitle>Spectrum</stitle><addtitle>Microbiol Spectr</addtitle><date>2023-12-12</date><risdate>2023</risdate><volume>11</volume><issue>6</issue><spage>e0224823</spage><epage>e0224823</epage><pages>e0224823-e0224823</pages><issn>2165-0497</issn><eissn>2165-0497</eissn><abstract>The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate-typically growth on glucose-is associated with the repression of other carbohydrate utilization genes, but it is not clear to what extent catabolite repression is exerted by other sugars. We investigated the hierarchy of sugar utilization after substrate transitions in . For this, we determined the proteome and carbohydrate utilization capacity after growth on different sugars. The results show that the preparedness of cells for the utilization of "slower" sugars is not strictly determined by the growth rate. The data point to individual proteins relevant for various sugar transitions and suggest that the evolutionary history of the organism might be responsible for deviations from a strictly growth rate-related sugar catabolization hierarchy.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>37888986</pmid><doi>10.1128/spectrum.02248-23</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0003-3929-0423</orcidid><orcidid>https://orcid.org/0000-0002-0847-8821</orcidid><orcidid>https://orcid.org/0000-0001-8596-0171</orcidid><orcidid>https://orcid.org/0000-0003-3604-7524</orcidid><orcidid>https://orcid.org/0000-0002-8224-0993</orcidid><orcidid>https://orcid.org/0000-0002-0091-5687</orcidid><orcidid>https://orcid.org/0000-0001-8552-2235</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2165-0497
ispartof Microbiology spectrum, 2023-12, Vol.11 (6), p.e0224823-e0224823
issn 2165-0497
2165-0497
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_a1e0b7c5ea134db993acd08a84a5d4ae
source American Society for Microbiology Journals; PubMed Central
subjects catabolism
catabolite repression
Lactococcus
proteome
Research Article
sugar transition
Systems Biology
title The hierarchy of sugar catabolization in Lactococcus cremoris
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T21%3A22%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20hierarchy%20of%20sugar%20catabolization%20in%20Lactococcus%20cremoris&rft.jtitle=Microbiology%20spectrum&rft.au=Douwenga,%20Sieze&rft.date=2023-12-12&rft.volume=11&rft.issue=6&rft.spage=e0224823&rft.epage=e0224823&rft.pages=e0224823-e0224823&rft.issn=2165-0497&rft.eissn=2165-0497&rft_id=info:doi/10.1128/spectrum.02248-23&rft_dat=%3Cproquest_doaj_%3E2883582310%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a457t-21f938f833d82713d103e97b52ce22267feb78dd23091f6fef393857d14775983%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2883582310&rft_id=info:pmid/37888986&rfr_iscdi=true