Liver Remodeling on CT Examination in Patients with HCV Compensated Cirrhosis Who Achieved Sustained Virological Response after Direct-Acting Antivirals Treatment

• Published in: Medicina (Kaunas, Lithuania) Lithuania), 2020-04, Vol.56 (4), p.171
• Main Authors: Mihai, Florin, Trifan, Anca, Stanciu, Carol, Singeap, Ana Maria, Cucuteanu, Bogdan, Lupascu Ursulescu, Corina, Pop, Corina, Girleanu, Irina, Cuciureanu, Tudor, Negru, Dragos, Cojocariu, Camelia
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antiviral Agents - therapeutic use; computed tomography; Female; Hepatitis C - complications; Hepatitis C - drug therapy; Hepatitis C - physiopathology; hepatitis C virus; Humans; Liver - abnormalities; Liver - physiopathology; liver cirrhosis; Liver Cirrhosis - complications; Liver Cirrhosis - drug therapy; liver fibrosis; Male; Middle Aged; Prospective Studies; Sustained Virologic Response; Tomography, X-Ray Computed - methods
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina56040171

The purpose of this study was to assess the changes in hepatic morphology evaluated by computed tomography (CT) examination in patients with hepatitis C virus (HCV)-related compensated cirrhosis who achieved sustained virologic response (SVR) after direct-acting antivirals (DAAs) treatment. CT examination was performed in 56 patients with HCV-related compensated cirrhosis before and within 6-18 months after the treatment with Ombitasvir/Paritaprevir/ritonavir + Dasabuvir. The liver CT changes were assessed by measuring liver volume, caudate-right lobe ratio (C/RL), hepatic vessels diameters, periportal widening space, and right posterior notch. Portal trunk, splenic and superior mesenteric vein diameters, as well as spleen volume were assessed as part of portal hypertension. Right hepatic vein diameter was significantly wider after treatment (median: 8.12 mm; IQR: 4.20) than before treatment (median: 6.36 mm; IQR: 3.94) z = -3.894; < 0.001. The liver volume was significantly higher prior to the treatment (median: 1786.77 mm ; IQR: 879.23) than after treatment (median: 1716.44 mm ; IQR: 840.50), z = -1.970; = 0.049. Splenic volume was considerably higher before treatment (median: 564.79 mm ; IQR: 342.54) than after (median: 474.45 mm ; IQR: 330.00), z = -2.500; = 0.012. The other parameters, such as C/RL, periportal space widening, and right hepatic notch showed no significant changes. SVR in patients with HCV-related compensated cirrhosis treated with DAAs is associated with some improvements of hepatic morphology detectable by CT, the most constant being the increase of right hepatic vein diameter.