Pathogenic role of PFKFB3 in endothelial inflammatory diseases

The differentiation of vascular endothelial cells and the formation of new blood vessels are inseparable from the energy supply and regulation of metabolism. The budding of blood vessels is a starting point of glycolysis pathway in angiogenesis. Phosphofructokinase-2/fructose 2,6-biophosphatase 3 (P...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in molecular biosciences 2024-09, Vol.11, p.1454456
Main Authors: Zhou, Ling, Li, Juan, Wang, Juanjuan, Niu, Xuping, Li, Junqin, Zhang, Kaiming
Format: Article
Language:English
Subjects:
3PO
endothelial cells
glycolysis
inflammatory
Molecular Biosciences
PFKFB3
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The differentiation of vascular endothelial cells and the formation of new blood vessels are inseparable from the energy supply and regulation of metabolism. The budding of blood vessels is a starting point of glycolysis pathway in angiogenesis. Phosphofructokinase-2/fructose 2,6-biophosphatase 3 (PFKFB3), a key rate-limiting enzyme in glycolysis, exhibits strong kinase activity. Inhibition of PFKFB3 can reduce the rate of glycolysis, thereby inhibiting the budding of blood vessels, resulting in inhibition of pathological angiogenesis. In this review, the role of PFKFB3 in the angiogenesis of inflammatory diseases was summarized, and the endothelial inflammatory diseases associated with PFKFB3 were reviewed.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2024.1454456