Correlation of anti-inflammatory activity with phenolic content in the leaves of syzygium cumini (l.) skeels (myrtaceae)

Phenolic contents of extracts of Syzygium cumini leaves, collected monthly over a one-year period, were quantitatively determined by the modified Folin-Ciocalteau method. Extracts and tannin-free fractions were assayed by their potential to inhibit mouse paw edema induced by C48/80. HPLC showed high...

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Bibliographic Details
Published in:Química Nova 2007-08, Vol.30 (4), p.860-864
Main Authors: Lima, Lucilene Azevedo, Siani, Antonio Carlos, Brito, Fabíola Almeida, Sampaio, André Luís Franco, Henriques, Maria das Graças Müller Oliveira, Riehl, Carlos Alberto da Silva
Format: Article
Language:English
Subjects:
anti-inflammatory
CHEMISTRY, MULTIDISCIPLINARY
seasonal variation
Syzygium cumin
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Summary:Phenolic contents of extracts of Syzygium cumini leaves, collected monthly over a one-year period, were quantitatively determined by the modified Folin-Ciocalteau method. Extracts and tannin-free fractions were assayed by their potential to inhibit mouse paw edema induced by C48/80. HPLC showed high molecular weight phenolic species and flavonoids in the active extracts and fractions. The highest total phenolic content corresponded to the most potent degree of inhibition and the flavonoids were supposed to be the main species responsible for the activity, given that the flavonoid-enriched ethyl-acetate fraction maintained its effect down to a dose of 0.01 mg/kg in a dose-response manner.
ISSN:0100-4042
1678-7064
1678-7064
DOI:10.1590/S0100-40422007000400019