Correlation of anti-inflammatory activity with phenolic content in the leaves of syzygium cumini (l.) skeels (myrtaceae)

Phenolic contents of extracts of Syzygium cumini leaves, collected monthly over a one-year period, were quantitatively determined by the modified Folin-Ciocalteau method. Extracts and tannin-free fractions were assayed by their potential to inhibit mouse paw edema induced by C48/80. HPLC showed high...

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Published in:Química Nova 2007-08, Vol.30 (4), p.860-864
Main Authors: Lima, Lucilene Azevedo, Siani, Antonio Carlos, Brito, Fabíola Almeida, Sampaio, André Luís Franco, Henriques, Maria das Graças Müller Oliveira, Riehl, Carlos Alberto da Silva
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Language:English
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anti-inflammatory
CHEMISTRY, MULTIDISCIPLINARY
seasonal variation
Syzygium cumin
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container_title Química Nova
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creator Lima, Lucilene Azevedo
Siani, Antonio Carlos
Brito, Fabíola Almeida
Sampaio, André Luís Franco
Henriques, Maria das Graças Müller Oliveira
Riehl, Carlos Alberto da Silva
description Phenolic contents of extracts of Syzygium cumini leaves, collected monthly over a one-year period, were quantitatively determined by the modified Folin-Ciocalteau method. Extracts and tannin-free fractions were assayed by their potential to inhibit mouse paw edema induced by C48/80. HPLC showed high molecular weight phenolic species and flavonoids in the active extracts and fractions. The highest total phenolic content corresponded to the most potent degree of inhibition and the flavonoids were supposed to be the main species responsible for the activity, given that the flavonoid-enriched ethyl-acetate fraction maintained its effect down to a dose of 0.01 mg/kg in a dose-response manner.
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subjects anti-inflammatory
CHEMISTRY, MULTIDISCIPLINARY
seasonal variation
Syzygium cumin
title Correlation of anti-inflammatory activity with phenolic content in the leaves of syzygium cumini (l.) skeels (myrtaceae)
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