Investigation into the effect of varied functional biointerfaces on silicon nanowire MOSFETs

A biocompatible and functional interface can improve the sensitivity of bioelectronics. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2012-12, Vol.12 (12), p.16867-16878
Main Authors: Lin, Shu-Ping, Chi, Tien-Yin, Lai, Tung-Yen, Liu, Mao-Chen
Format: Article
Language:English
Subjects:
Antigens
Atomic force microscopy
Biomolecules
Biosensing Techniques
Buffer solutions
Detection
electrical measurement
functional biointerface
Hydrogen-Ion Concentration
Investigations
Microscopy, Atomic Force
Nanomaterials
Nanostructure
Nanowires
Nanowires - chemistry
pH sensing
Physiology
protein interaction
Protein Interaction Maps
Proteins
Semiconductors
Sensors
Silanes - chemistry
Silicon
Silicon - chemistry
surface modification
Surface Properties
Transistors
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Summary:A biocompatible and functional interface can improve the sensitivity of bioelectronics. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor field effect transistors (NW-MOSFETs). Those SAMs-modified silicon NW-MOSFETs were used to discriminate various pH solutions and further verify which modified regime was capable of providing better electrical signals. The APTMS-SAM modified NW-MOSFETs showed better electrical responses in pH sensing. Biomolecules on APTMS-SAM modified NW-MOSFETs also gave better signals for the corresponding proteind in physiological buffer solutions. Atomic force microscopy (AFM) clarified those electrical phenomena and found biomolecules on APTMS-SAM were relatively uniformly modified on NW-MOSFETs. Our results showed that more uniform modification contributed to better signal response to protein interactions in physiological buffer solutions. It suggests that suitable surface modifications could profoundly affect the sensing response and sensitivity.
ISSN:1424-8220
1424-8220
DOI:10.3390/s121216867