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Investigation into the effect of varied functional biointerfaces on silicon nanowire MOSFETs

A biocompatible and functional interface can improve the sensitivity of bioelectronics. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor...

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Published in:	Sensors (Basel, Switzerland) Switzerland), 2012-12, Vol.12 (12), p.16867-16878
Main Authors:	Lin, Shu-Ping, Chi, Tien-Yin, Lai, Tung-Yen, Liu, Mao-Chen
Format:	Article
Language:	English
Subjects:	Antigens Atomic force microscopy Biomolecules Biosensing Techniques Buffer solutions Detection electrical measurement functional biointerface Hydrogen-Ion Concentration Investigations Microscopy, Atomic Force Nanomaterials Nanostructure Nanowires Nanowires - chemistry pH sensing Physiology protein interaction Protein Interaction Maps Proteins Semiconductors Sensors Silanes - chemistry Silicon Silicon - chemistry surface modification Surface Properties Transistors
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container_title	Sensors (Basel, Switzerland)
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creator	Lin, Shu-Ping Chi, Tien-Yin Lai, Tung-Yen Liu, Mao-Chen
description	A biocompatible and functional interface can improve the sensitivity of bioelectronics. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor field effect transistors (NW-MOSFETs). Those SAMs-modified silicon NW-MOSFETs were used to discriminate various pH solutions and further verify which modified regime was capable of providing better electrical signals. The APTMS-SAM modified NW-MOSFETs showed better electrical responses in pH sensing. Biomolecules on APTMS-SAM modified NW-MOSFETs also gave better signals for the corresponding proteind in physiological buffer solutions. Atomic force microscopy (AFM) clarified those electrical phenomena and found biomolecules on APTMS-SAM were relatively uniformly modified on NW-MOSFETs. Our results showed that more uniform modification contributed to better signal response to protein interactions in physiological buffer solutions. It suggests that suitable surface modifications could profoundly affect the sensing response and sensitivity.
doi_str_mv	10.3390/s121216867
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Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor field effect transistors (NW-MOSFETs). Those SAMs-modified silicon NW-MOSFETs were used to discriminate various pH solutions and further verify which modified regime was capable of providing better electrical signals. The APTMS-SAM modified NW-MOSFETs showed better electrical responses in pH sensing. Biomolecules on APTMS-SAM modified NW-MOSFETs also gave better signals for the corresponding proteind in physiological buffer solutions. Atomic force microscopy (AFM) clarified those electrical phenomena and found biomolecules on APTMS-SAM were relatively uniformly modified on NW-MOSFETs. Our results showed that more uniform modification contributed to better signal response to protein interactions in physiological buffer solutions. 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subjects	Antigens Atomic force microscopy Biomolecules Biosensing Techniques Buffer solutions Detection electrical measurement functional biointerface Hydrogen-Ion Concentration Investigations Microscopy, Atomic Force Nanomaterials Nanostructure Nanowires Nanowires - chemistry pH sensing Physiology protein interaction Protein Interaction Maps Proteins Semiconductors Sensors Silanes - chemistry Silicon Silicon - chemistry surface modification Surface Properties Transistors
title	Investigation into the effect of varied functional biointerfaces on silicon nanowire MOSFETs
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